Zeng Y, Sun QM, Liu NN, Dong GH, Chen J, Yang L, Wang B. Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population. World J Gastroenterol 2010; 16(28): 3578-3583 [PMID: 20653068 DOI: 10.3748/wjg.v16.i28.3578]
Corresponding Author of This Article
Bin Wang, Professor, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. binwangnjmu@gmail.com
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Brief Article
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World J Gastroenterol. Jul 28, 2010; 16(28): 3578-3583 Published online Jul 28, 2010. doi: 10.3748/wjg.v16.i28.3578
Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population
Ying Zeng, Qing-Min Sun, Nan-Nan Liu, Guang-Hui Dong, Jie Chen, Li Yang, Bin Wang
Ying Zeng, Nan-Nan Liu, Guang-Hui Dong, Jie Chen, Bin Wang, Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Qing-Min Sun, The Affiliated Wuxi Hospital for Maternal and Child Health Care of Nanjing Medical University, Wuxi 214002, Jiangsu Province, China
Li Yang, Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Zeng Y participated in the study design, conducted polymerase chain reaction-restriction fragment length polymorphism, analyzed the data, wrote the manuscript; Sun QM and Liu NN participated in the study design, extracted genetic DNA from all blood samples; Dong GH, Yang L and Chen J collected blood samples from the Affiliated Hospital of Nanjing Medical University; Wang B designed and coordinated the study and revised the manuscript.
Supported by National Natural Science Foundation of China, No. 30873099; Natural Science Foundation of Jiangsu Province, No. BK2006525; No. 08KJB320004, “333 Project” and “Qinglan Project” Funds for the Young Academic Leader of Jiangsu Province to Wang B
Correspondence to: Bin Wang, Professor, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. binwangnjmu@gmail.com
Telephone: +86-25-86862884 Fax: +86-25-86862884
Received: March 17, 2010 Revised: May 20, 2010 Accepted: May 27, 2010 Published online: July 28, 2010
Abstract
AIM: To investigate the association between pre-miR-146a C/G polymorphism and gastric cancer risk.
METHODS: We performed a hospital-based, case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals (304 gastric cancer patients and 304 age and sex matched cancer-free controls).
RESULTS: The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups (P = 0.037). Compared with CC genotype carriers, subjects with the variant genotypes (GC + GG) had a 58% increased risk of gastric cancer (adjusted OR = 1.58, 95% CI: 1.11-2.20, P = 0.009). Moreover, a higher gastric cancer risk was especially evident in younger individuals aged ≤ 58 years, nonsmokers, and males (adjusted OR = 1.76, 95% CI: 1.08-2.87, P = 0.024; adjusted OR = 1.55, 95% CI: 1.06-2.28, P = 0.025; adjusted OR = 1.53, 95% CI: 1.04-2.27, P = 0.033; respectively).
CONCLUSION: Pre-miR-146a C/G polymorphism might be associated with an elevated risk of gastric cancer in Chinese population.
