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World J Gastroenterol. Jan 14, 2010; 16(2): 279-280
Published online Jan 14, 2010. doi: 10.3748/wjg.v16.i2.279
Published online Jan 14, 2010. doi: 10.3748/wjg.v16.i2.279
Controversies about the use of serological markers in diagnosis of inflammatory bowel disease
Qin Xie, Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Hua-Tian Gan, Department of Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Xie Q and Gan HT contributed equally to this work.
Correspondence to: Hua-Tian Gan, MD, PhD, Department of Geriatric Medicine and Gastroenterology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. ganhuatian@hotmail.com
Telephone: +86-28-85423253 Fax: +86-28-85423253
Received: November 14, 2009
Revised: December 11, 2009
Accepted: December 18, 2009
Published online: January 14, 2010
Revised: December 11, 2009
Accepted: December 18, 2009
Published online: January 14, 2010
Abstract
The serological markers are increasingly used in diagnosis of inflammatory bowel disease (IBD). D-lactate and diamine oxidase are new indicators that can be used to reveal the damage to intestinal mucosa and permeability alteration in IBD. Although the two biological markers seem more sensitive, recent clinical trials and animal experiments have shown controversies about the use of them in diagnosis of IBD. Therefore, these markers should be interpreted cautiously and further prospective studies are needed to establish their clinical role in diagnosis of IBD.
Keywords: Inflammatory bowel diseases, D-lactate, Diamine oxidase, Intestinal permeability, Diagnosis