Brief Article
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. May 21, 2010; 16(19): 2407-2410
Published online May 21, 2010. doi: 10.3748/wjg.v16.i19.2407
Alkaline phosphatase predicts relapse in chronic hepatitis C patients with end-of-treatment response
Gerd Bodlaj, Rainer Hubmann, Karim Saleh, Tatjana Stojakovic, Georg Biesenbach, Jörg Berg
Gerd Bodlaj, Rainer Hubmann, Karim Saleh, Georg Biesenbach, Second Department of Medicine, General Hospital Linz, A-4020 Linz, Austria
Tatjana Stojakovic, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, A-8010 Graz, Austria
Jörg Berg, Institute of Laboratory Medicine, General Hospital Linz, A-4020 Linz, Austria
Author contributions: Bodlaj G analyzed the data, drafted the article and provided intellectual content of critical importance to the work; Hubmann R provided intellectual content of critical importance to the work; Saleh K participated in the collection and analyses of data; Stojakovic T participated in the analyses of data; Biesenbach G provided intellectual content of critical importance to the work; Berg J revised and edited the manuscript and provided intellectual content of critical importance to the work.
Correspondence to: Gerd Bodlaj, MD, Second Department of Medicine, General Hospital Linz, Krankenhausstr. 9, A-4020 Linz, Austria. gerd.bodlaj@akh.linz.at
Telephone: +43-732-780673278 Fax: +43-732-7806747278
Received: January 3, 2010
Revised: February 10, 2010
Accepted: February 17, 2010
Published online: May 21, 2010
Abstract

AIM: To investigate relapse predictors in chronic hepatitis C (CHC) patients with end-of-treatment response (ETR), after pegylated interferon-α (PegIFN-α) and ribavirin treatment.

METHODS: In a retrospective study we evaluated a spectrum of predictors of relapse after PegIFN-α and ribavirin treatment in 86 CHC patients with ETR. Viral loads were determined with real-time reverse transcription polymerase chain reaction. Hepatitis C virus genotyping was performed by sequencing analysis. Patients with genotype 1 were treated for 48 wk with 180 μg PegIFN-α2a or 1.5 μg/kg PegIFN-α2b once weekly plus ribavirin at a dosage of 1000 mg/d for those under 75 kg or 1200 mg/d for those over 75 kg. Patients with genotypes 2 and 3 were treated for 24 wk with 180 μg PegIFN-α2a or 1.5 μg/kg PegIFN-α2b once weekly plus ribavirin at a dosage of 800 mg/d.

RESULTS: In all ETR patients, binary logistic regression analysis identified absence of complete early virological response (cEVR) (OR 27.07, 95% CI: 3.09-237.26, P < 0.005), serum alkaline phosphatase (ALP) levels prior to therapy < 75 U/L (OR: 6.16, 95% CI: 2.1-18.03, P < 0.001) and body mass index > 26 kg/m2 (OR: 8.27, 95% CI: 2.22-30.84, P < 0.005) as independent predictors of relapse. When cEVR patients were analyzed exclusively, ALP prior to therapy < 75 U/L remained the only predictor of relapse.

CONCLUSION: Lower levels of ALP prior to, during and after therapy seem to be associated with a higher risk of relapse in CHC patients with ETR.

Keywords: Alkaline phosphatase, Chronic hepatitis C, Pegylated interferon, Predictor, Relapse