Basaranoglu M, Kayacetin S, Yilmaz N, Kayacetin E, Tarcin O, Sonsuz A. Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol 2010; 16(18): 2223-2226 [PMID: 20458758 DOI: 10.3748/wjg.v16.i18.2223]
Corresponding Author of This Article
Dr. Metin Basaranoglu, Division of Gastroenterology, Ankara Yüksek Ihtisas Hospital, Ankara 06100, Turkey. metin_basaranoglu@yahoo.com
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World J Gastroenterol. May 14, 2010; 16(18): 2223-2226 Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2223
Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease
Metin Basaranoglu, Serra Kayacetin, Nevin Yilmaz, Ertugrul Kayacetin, Orhan Tarcin, Abdullah Sonsuz
Metin Basaranoglu, Division of Gastroenterology, Ankara Yüksek Ihtisas Hospital, Ankara 06100, Turkey
Serra Kayacetin, Department of Pathology, Konya Education and Teaching Hospital, Konya 42080, Turkey
Nevin Yilmaz, Mugla University, School of Medicine, GI/Transplant Hepatology, Kötekli, Mugla 48120, Turkey
Ertugrul Kayacetin, Division of Gastroenterology, Meram Medical Faculty, Selcuk University, Konya 42080, Turkey
Orhan Tarcin, Division of Gastroenterology, Yeni Yüzyil University, Istanbul 34000, Turkey
Abdullah Sonsuz, Division of Gastroenterology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34000, Turkey
Author contributions: Basaranoglu M contributed extensively to the work, performed literature search and designed and wrote the paper; Kayacetin S, Yilmaz N, Tarcin O, Sonsuz A and Kayacetin E contributed equally to this work; Kayacetin S and Kayacetin E performed literature search; all authors discussed and commented on the manuscript.
Correspondence to: Dr. Metin Basaranoglu, Division of Gastroenterology, Ankara Yüksek Ihtisas Hospital, Ankara 06100, Turkey. metin_basaranoglu@yahoo.com
Telephone: +90-212-5540570 Fax: +90-212-6217580
Received: December 3, 2009 Revised: February 20, 2010 Accepted: February 27, 2010 Published online: May 14, 2010
Abstract
A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood. In the setting of excessive central adiposity, insulin resistance is the major underlying cause of fat accumulation in hepatocytes. Because of the difficulties with human trials, several animal models have been developed for this purpose mainly characterized as follows: genetically disturbed or murine fatty liver, methionine-choline deficient diet fed or murine steatohepatitis, and high-fat or sucrose diet fed models. Although these animal models have provided useful information, none of them accurately reflect genetic, metabolic and biochemical characteristics of the human disease.
