Brief Article
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. May 7, 2010; 16(17): 2170-2175
Published online May 7, 2010. doi: 10.3748/wjg.v16.i17.2170
Peroxisome proliferator-activated receptor-γ 34C>G polymorphism and colorectal cancer risk: A meta-analysis
Yong-Liang Lu, Gai-Ling Li, Hui-Lian Huang, Jing Zhong, Li-Cheng Dai
Yong-Liang Lu, Department of Surgery, Huzhou Teachers College School of Medicine, Huzhou 313000, Zhejiang Province, China
Gai-Ling Li, SIP Healo & Halo Life Science Research Center, Suzhou 215000, Jiangsu Province, China
Hui-Lian Huang, Jing Zhong, Li-Cheng Dai, Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China
Author contributions: Li GL, Huang HL and Zhong J collected the materials and analyzed the data; Lu YL and Dai LC designed the study and wrote the manuscript.
Supported by The National Natural Science Foundation of China, No. 30772534
Correspondence to: Li-Cheng Dai, Professor, Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China. dlc@hzhospital.com
Telephone: +86-572-2033020 Fax: +86-572-2033020
Received: January 31, 2010
Revised: March 1, 2010
Accepted: March 8, 2010
Published online: May 7, 2010
Abstract

AIM: To investigate the association between peroxisome proliferator-activated receptor-γ (PPAR-γ) gene polymorphism 34 C>G and colorectal cancer (CRC), a meta-analysis review was performed in this report.

METHODS: A systematic literature search and selection of eligible relevant studies were carried out. Nine independent studies with a total number of 4533 cases and 6483 controls were included in the meta-analysis on the association between polymorphism 34 C>G and CRC.

RESULTS: There was no evidence for the association between PPAR-γ 34 C>G and CRC if all of the subjects in the nine studies were included. However, CG + GG showed a marginally significant difference from CC (OR = 0.84, 95% CI: 0.69-1.01, P = 0.07) in random-effect model. Stratified meta-analysis indicated that PPAR-γ 34 C>G was associated with colon cancer (OR = 0.8, 95% CI: 0.65-0.99, P = 0.04) in random-effect model, and the G allele decreased colon cancer risk. No significant association was observed between PPAR-γ 34 C>G and rectal cancer.

CONCLUSION: PPAR-γ 34 C>G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk.

Keywords: Peroxisome proliferator-activated receptor-γ, Colorectal cancer, Polymorphism, Meta-analysis