Ikeuchi N, Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T, Ishii K, Tsuji S, Umeda J, Moriyasu F, Tsuchida A, Kasuya K. Prognosis of cancer with branch duct type IPMN of the pancreas. World J Gastroenterol 2010; 16(15): 1890-1895 [PMID: 20397268 DOI: 10.3748/wjg.v16.i15.1890]
Corresponding Author of This Article
Takao Itoi, MD, PhD, Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjyuku, Shinjyuku-ku, Tokyo 160-0023, Japan. itoi@tokyo-med.ac.jp
Article-Type of This Article
Brief Article
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Nobuhito Ikeuchi, Takao Itoi, Atsushi Sofuni, Fumihide Itokawa, Takayoshi Tsuchiya, Toshio Kurihara, Kentaro Ishii, Shujiro Tsuji, Junko Umeda, Fuminori Moriyasu, Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo 160-0023, Japan
Akihiko Tsuchida, Kazuhiko Kasuya, Department of Surgery, Tokyo Medical University, Tokyo 160-0023, Japan
Author contributions: Ikeuchi N and Itoi T contributed equally to this work; Ikeuchi N, Itoi T, Sofuni A, Itokawa F, Kurihara T, Tsuchiya T, Ishii K, Tsuji S and Umeda J performed the research and collected the data; Ikeuchi N, Itoi T, Moriyasu F, Kasuya K and Tsuchida A reviewed the data analysis.
Correspondence to: Takao Itoi, MD, PhD, Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjyuku, Shinjyuku-ku, Tokyo 160-0023, Japan. itoi@tokyo-med.ac.jp
Telephone: +81-3-33426111 Fax: +81-3-53816654
Received: November 12, 2009 Revised: December 19, 2009 Accepted: December 26, 2009 Published online: April 21, 2010
Abstract
AIM: To examine the coexistence of metachronous and synchronous cancer in branch duct intraductal papillary mucinous neoplasms of the pancreas (IPMN).
METHODS: We reviewed the records of 145 patients with branch duct IPMN between January 1991 and April 2008 and assessed the relationship between IPMN and intra- or extra-pancreatic carcinoma and the outcome of IPMN.
RESULTS: The mean observation period was 55.9 ± 45.3 mo. Among the 145 patients, the frequency of extra-pancreatic cancer was 29.0%. The frequency of gastric cancer, colon cancer, breast cancer, and pancreatic cancer were 25.5%, 15.7%, 13.7%, and 9.8%, respectively. Twenty (13.8%) of the patients died. The cause of death was extra-pancreatic carcinoma in 40%, pancreatic cancer in 25%, IPMN per se in 20%, and benign disease in 15% of the patients.
CONCLUSION: The prognosis for IPMN depends not on the IPMN per se, but on the presence of intra- or extra-pancreatic cancer.
