Hao HF, Naomoto Y, Bao XH, Watanabe N, Sakurama K, Noma K, Tomono Y, Fukazawa T, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M. Progress in researches about focal adhesion kinase in gastrointestinal tract. World J Gastroenterol 2009; 15(47): 5916-5923 [PMID: 20014455 DOI: 10.3748/wjg.15.5916]
Corresponding Author of This Article
Yoshio Naomoto, MD, PhD, MBA, Department of Gastroenterological Surgery, Transplantation and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. ynaomoto@md.okayama-u.ac.jp
Article-Type of This Article
Review
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Hui Fang Hao, Yoshio Naomoto, Xiao-Hong Bao, Nobuyuki Watanabe, Kazufumi Sakurama, Kazuhiro Noma, Takuya Fukazawa, Yasuhiro Shirakawa, Tomoki Yamatsuji, Junji Matsuoka, Munenori Takaoka, Department of Gastroenterological Surgery, Transplantation and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
Yasuko Tomono, Shigei Medical Research Institute, Okayama 700-8558, Japan
Author contributions: Naomoto Y gave the idea; Bao XH, Watanabe N, Sakurama K, Noma K, Tomono Y, Fukazawa T, Shirakawa Y, Yamatsuji T, Matsuoka J and Takaoka M modified the paper; Hao HF wrote the paper.
Correspondence to: Yoshio Naomoto, MD, PhD, MBA, Department of Gastroenterological Surgery, Transplantation and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. ynaomoto@md.okayama-u.ac.jp
Telephone: +81-86-2357257 Fax: +81-86-2218775
Received: August 11, 2009 Revised: October 10, 2009 Accepted: October 17, 2009 Published online: December 21, 2009
Abstract
Focal adhesion kinase (FAK) is a 125-kDa non-receptor protein tyrosine. Growth factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein tyrosine kinases, resulting in the phosphorylation of Tyr-576 and Tyr-577 in the FAK activation loop and full catalytic FAK activation. FAK plays a critical role in the biological processes of normal and cancer cells including the gastrointestinal tract. FAK also plays an important role in the restitution, cell survival and apoptosis and carcinogenesis of the gastrointestinal tract. FAK is over-expressed in cancer cells and its over-expression and elevated activities are associated with motility and invasion of cancer cells. FAK has been proposed as a potential target in cancer therapy. Small molecule inhibitors effectively inhibit the kinase activity of FAK and show a potent inhibitory effect for the proliferation and migration of tumor cells, indicating a high potential for application in cancer therapy.
