Čolović RB, Matić SV, Micev MT, Grubor NM, Atkinson HD, Latinčić SM. Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient. World J Gastroenterol 2009; 15(46): 5859-5863 [PMID: 19998510 DOI: 10.3748/wjg.15.5859]
Corresponding Author of This Article
Slavko V Matić, MD, PhD, Associate Professor of Surgery, Clinical Center of Serbia, Institute for Digestive diseases, K. Todorovića 6 street, Belgrade 11000, Serbia. slavko.matic@med.bg.ac.rs
Article-Type of This Article
Case Report
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World J Gastroenterol. Dec 14, 2009; 15(46): 5859-5863 Published online Dec 14, 2009. doi: 10.3748/wjg.15.5859
Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient
Radoje B Čolović, Slavko V Matić, Marjan T Micev, Nikica M Grubor, Henry Dushan Atkinson, Stojan M Latinčić
Radoje B Čolović, Slavko V Matić, Marjan T Micev, Nikica M Grubor, Stojan M Latinčić, The First Surgical Clinic, Clinical Center of Serbia, Koste Todorovića 6, Belgrade 11000, Serbia
Henry Dushan Atkinson, Surgical Directorate, Imperial College School of Medicine, St Mary’s Hospital, Praed St, London W2 1NY, United Kindom
Author contributions: Čolović RB and Latinčić SM operated on the patient, Čolović RB and Matić SV wrote the paper, Matić SV and Grubor NM performed the literature research and analysis, Micev MT did all the pathological and immunohistochemical examinations, Atkinson HD revised the English translation of the article.
Correspondence to: Slavko V Matić, MD, PhD, Associate Professor of Surgery, Clinical Center of Serbia, Institute for Digestive diseases, K. Todorovića 6 street, Belgrade 11000, Serbia. slavko.matic@med.bg.ac.rs
Telephone: +381-64-2181949 Fax: +381-11-3031830
Received: October 23, 2009 Revised: November 12, 2009 Accepted: November 19, 2009 Published online: December 14, 2009
Abstract
Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract, first described in the pancreas in 1977 and in the duodenum in 1979. They may be functional and cause somatostatinoma or inhibitory syndrome, but more frequently are non-functioning pancreatic endocrine tumors that produce somatostatin alone. They are usually single, malignant, large lesions, frequently associated with metastases, and generally with poor prognosis. We present the unique case of a 57-year-old woman with two synchronous non-functioning somatostatinomas, one solid duodenal lesion and one cystic lesion within the head of the pancreas, that were successfully resected with a pylorus-preserving Whipple’s procedure. No secondaries were found in the liver, or in any of the removed regional lymph nodes. The patient had an uneventful recovery, and remains well and symptom-free at 18 mo postoperatively. This is an extremely rare case of a patient with two synchronous somatostatinomas of the duodenum and the pancreas. The condition is discussed with reference to the literature.
