Leu JD, Lin IF, Sun YF, Chen SM, Liu CC, Lee YJ. Association between MDM2-SNP309 and hepatocellular carcinoma in Taiwanese population. World J Gastroenterol 2009; 15(44): 5592-5597 [PMID: 19938200 DOI: 10.3748/wjg.15.5592]
Corresponding Author of This Article
Dr. Yi-Jang Lee, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Sec. 2, Linong St. Beitou District, 112 Taipei, Taiwan, China. yjlee2@ym.edu.tw
Article-Type of This Article
Brief Article
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Jyh-Der Leu, Division of Radiation Oncology, Taipei City Hospital Ren Ai Branch, 10629 Taipei, Taiwan, China
I-Feng Lin, Department of Public Health, National Yang-Ming University, 112 Taipei, Taiwan, China
Ying-Fang Sun, Yi-Jang Lee, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, 112 Taipei, Taiwan, China
Su-Mei Chen, Division of Nuclear Medicine, Taipei City Hospital Ren Ai Branch, 10629 Taipei, Taiwan, China
Chih-Chao Liu, Institute of Environmental and Occupational Healthy Sciences, National Yang-Ming University, 112 Taipei, Taiwan, China
Author contributions: Leu JD was responsible for case and control number design and evaluation; Lin IF and Liu CC performed the statistical analysis and provided interpretation of the results; Sun YF was responsible for DNA extraction and MDM2 SNP309 genotyping; Chen SM was responsible for collection of blood samples, signed consent forms and filled questionnaires; Lee YJ designed the study, carried out the genotyping, investigated the progression of this study and prepared the manuscript; all co-authors read and approved this final manuscript.
Supported by The Department of Health in Taipei City Government, Grant No. 95003-62-129 and a grant from Ministry of Education, aim for the Top University Plan; National Science Council Grant (NSC 96-2321-B-010-006-MY3)
Correspondence to: Dr. Yi-Jang Lee, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Sec. 2, Linong St. Beitou District, 112 Taipei, Taiwan, China. yjlee2@ym.edu.tw
Telephone: +886-2-28267189 Fax: +886-2-28201095
Received: August 13, 2009 Revised: August 13, 2009 Accepted: October 1, 2009 Published online: November 28, 2009
Abstract
AIM: To investigate the risk association and compare the onset age of hepatocellular carcinoma (HCC) patients in Taiwan with different genotypes of MDM2-SNP309.
METHODS: We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls consecutively. Genotyping of MDM2-SNP309 was conducted by restriction fragment length polymorphism assay.
RESULTS: The proportion of homozygous MDM2-SNP309 genotype (G/G) in cases and cancer-free healthy controls was similar (17.2% vs 16.7%). Multivariate analysis showed that the risk of G/G genotype of MDM2-SNP309 vs wild-type T/T genotype in patients with HCC was not significant (OR = 1.265, 95% CI = 0.074-21.77) after adjustment for sex, hepatitis B or C virus infection, age, and cardiovascular disease/diabetes. Nevertheless, there was a trend that GG genotype of MDM2-SNP309 might increase the risk in HCC patients infected with hepatitis virus (OR = 2.568, 95% CI = 0.054-121.69). Besides, the homozygous MDM2-SNP309 genotype did not exhibit a significantly earlier age of onset for HCC.
CONCLUSION: Current data suggest that the association between MDM2-SNP309 GG genotype and HCC is not significant, while the risk may be enhanced in patients infected by hepatitis virus in Taiwan.
