Brief Article
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Oct 28, 2009; 15(40): 5097-5102
Published online Oct 28, 2009. doi: 10.3748/wjg.15.5097
Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan
Yuji Mizokami
Yuji Mizokami, Gamagori City Hospital, 1-1 Mukaida, Hirata-Chou, Gamagori, Aichi 443-8501, Japan
Author contributions: Mizokami Y designed the research, performed the research, analyzed the data and wrote the paper.
Correspondence to: Yuji Mizokami, PhD, MD, Gamagori City Hospital, 1-1 Mukaida, Hirata-Chou, Gamagori, Aichi 443-8501, Japan.
Telephone: +81-533-662200 Fax: +81-533-662295
Received: March 31, 2009
Revised: September 27, 2009
Accepted: October 4, 2009
Published online: October 28, 2009

AIM: To investigate the efficacy and safety of rabeprazole under continuous non-steroidal anti-inflammatory drug (NSAID) administration for NSAID-induced ulcer in Japan.

METHODS: Subjects comprised patients undergoing NSAID treatment in whom upper gastrointestinal endoscopy revealed an ulcerous lesion (open ulcer) with diameter ≥ 3 mm, who required continuous NSAID treatment. Endoscopies were performed at the start of treatment, during the treatment period, and at the conclusion (or discontinuation) of treatment. Findings were evaluated as size (maximum diameter) and stage based on the Sakita-Miwa classification. An ulcer was regarded as cured when the “white coating” was seen to have disappeared under endoscopy. As criteria for evaluating safety, all medically untoward symptoms and signs (adverse events, laboratory abnormalities, accidental symptoms, etc.) occurring after the start of rabeprazole treatment were handled as adverse events.

RESULTS: Endoscopic cure rate in 38 patients in the efficacy analysis (endoscopic evaluation) was 71.1% (27/38). Among those 38 patients, 35 had gastric ulcer with a cure rate of 71.4% (25/35), and 3 had duodenal ulcer with a cure rate of 66.7% (2/3). Three adverse drug reactions were reported from 64 patients in the safety analysis (interstitial pneumonia, low white blood cell count and pruritus); thus, the incidence rate for adverse drug reactions was 4.7% (3/64).

CONCLUSION: The treatment efficacy of rabeprazole for NSAID-induced ulcer under continuous NSAID administration was confirmed.

Keywords: Rabeprazole, Non-steroidal anti-inflammatory drug, Non-steroidal anti-inflammatory drug-induced ulcer, Endoscopic findings, Continuous non-steroidal anti-inflammatory drug administration