Phillips LS, Thompson CL, Merkulova A, Plummer SJ, Tucker TC, Casey G, Li L. No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer. World J Gastroenterol 2009; 15(30): 3771-3775 [PMID: 19673018 DOI: 10.3748/wjg.15.3771]
Corresponding Author of This Article
Li Li, MD, PhD, Department of Family Medicine, Research Division, Case Western Reserve University, 11001 Cedar Ave., Suite 306, Cleveland, Ohio 44106-7136, United States. li.li@case.edu
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Brief Articles
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World J Gastroenterol. Aug 14, 2009; 15(30): 3771-3775 Published online Aug 14, 2009. doi: 10.3748/wjg.15.3771
No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer
Lynette S Phillips, Cheryl L Thompson, Alona Merkulova, Sarah J Plummer, Thomas C Tucker, Graham Casey, Li Li
Lynette S Phillips, Department of Epidemiology and Biostatistics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106-7136, United States
Cheryl L Thompson, Li Li, Departments of Family Medicine and Epidemiology and Biostatistics, Case Center for Transdisciplinary Research on Energetics and Cancer, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106-7136, United States
Alona Merkulova, Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH 44195-0001, United States
Sarah J Plummer, Graham Casey, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033-1006, United States
Thomas C Tucker, Markey Cancer Center, University of Kentucky, Lexington, KY 40504-3381, United States
Author contributions: Phillips LS performed the statistical analyses and drafted the manuscript; Thompson CL assisted with the subject recruitment, data collection, and assisted with manuscript preparation; Merkulova A performed some of the genotyping; Plummer SJ conducted some of the genotyping; Tucker TC assisted with patient referrals, recruitment, and reviewed the manuscript; Casey G coordinated the lab work and reviewed the manuscript; Li L led the study design, data collection, and assisted with the manuscript preparation.
Correspondence to: Li Li, MD, PhD, Department of Family Medicine, Research Division, Case Western Reserve University, 11001 Cedar Ave., Suite 306, Cleveland, Ohio 44106-7136, United States. li.li@case.edu
Telephone: +1-216-3685437
Fax: +1-216-3684348
Received: June 3, 2009 Revised: July 17, 2009 Accepted: July 24, 2009 Published online: August 14, 2009
Abstract
AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer.
METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.
RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer.
CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.
