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©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Jul 14, 2009; 15(26): 3269-3275
Published online Jul 14, 2009. doi: 10.3748/wjg.15.3269
Color Doppler sonography and angioscintigraphy in hepatic Hodgkin’s lymphoma
Mirjana V Stojković, Vera M Artiko, Irena B Radoman, Slavko J Knežević, Snezana M Lukić, Mirko D Kerkez, Nebojsa S Lekić, Andrija A Antić, Marinko M Žuvela, Vitomir I Ranković, Milorad N Petrović, Dragana P Šobić, Vladimir B Obradović
Mirjana V Stojković, Snezana M Lukić, Mirko D Kerkez, Nebojsa S Lekić, Andrija A Antić, Marinko M Žuvela, Vitomir I Ranković, Milorad N Petrović, Institute for Digestive Diseases Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia
Vera M Artiko, Dragana P Šobić, Vladimir B Obradović, Institute for Nuclear Medicine, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia
Irena B Radoman, Gastroenterology Department, Clinical Center Podgorica, Ljubljanska 1, 81000 Podgorica, Montenegro
Slavko J Knežević, Gastroenterology Department, Clinical Center Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia
Author contributions: Stojković MV, Artiko VM, Kerkez MD, Petrović MN, Šobić DP, and Obradović VB contributed equally to this work; Stojković MV, Artiko VM, Kerkez MD, Petrović MN, Šobić DP, and Obradović VB designed research; Stojković MV, Artiko VM, Radoman IB, Knežević SJ, Lukić SM, Petrović MN, Kerkez MD, Lekić NS, Antić AA, Žuvela MM, Ranković VI helped in the appropriate choice of the patients and performed research; Stojković MV, Artiko VM, Šobić DP and Obradović VB analyzed data; Stojković MV wrote the paper.
Correspondence to: Vera M Artiko, Institute for Nuclear Medicine, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia. veraart@beotel.yu
Telephone: +381-11-3540891
Fax: +381-11-3540891
Received: February 3, 2009
Revised: May 23, 2009
Accepted: May 30, 2009
Published online: July 14, 2009
AIM: To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin’s hepatic lymphoma.
METHODS: The research included patients with a diagnosis of Hodgkin’s lymphoma with metastatic focal lesions in the liver and controls. Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal, hepatic and splenic veins were examined. Hepatic perfusion index (HPI) estimated by HRA was calculated.
RESULTS: In the majority of patients, hepatomegaly was observed. Lesions were mostly hypoechoic and mixed, solitary or multiple. Some of the patients presented with dilated splenic veins and hepatofugal blood flow. A pulse wave was registered in the centre and at the margins of lymphoma. The average velocity of the pulse wave was higher at the margins (P > 0.05). A continuous venous wave was found only at the margins of lymphoma. There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r = 390, P < 0.01). HPI was significantly lower in patients with lymphomas than in controls (P < 0.05), pointing out increased arterial perfusion in comparison to portal perfusion.
CONCLUSION: Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin’s hepatic lymphoma and estimation of its intensity. Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions.
