Guidelines Clinical Practice
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Jan 7, 2009; 15(1): 17-24
Published online Jan 7, 2009. doi: 10.3748/wjg.15.17
Eosinophilic esophagitis
Anand R Gupte, Peter V Draganov
Anand R Gupte, Peter V Draganov, Department of Gastroenterology, Hepatology and Nutrition, University of Florida, 1600 SW Archer Rd, Room HD 602, PO Box 100214 Gainesville, Florida 32610, United States
Author contributions: Gupte AR and Draganov PV have contributed equally.
Correspondence to: Peter V Draganov, MD, Department of Gastroenterology, Hepatology and Nutrition, University of Florida, 1600 SW Archer Rd, Room HD 602, PO Box 100214 Gainesville, Florida 32610, United States. dragapv@medicine.ufl.edu
Telephone: +1-352-392-2877
Fax: +1-352-392-3618
Received: June 20, 2008
Revised: December 3, 2008
Accepted: December 10, 2008
Published online: January 7, 2009
Abstract

Eosinophilic esophagitis is increasingly recognized in adults. The diagnosis is based on the presence of both typical symptoms and pathologic findings on esophageal biopsy. Patients usually present with dysphagia, food impaction and/or reflux-like symptoms, and biopsy of the esophagus shows more than 15 eosinophils per high-power field. In addition, it is essential to exclude the presence of known causes of tissue eosinophilia such as gastroesophageal reflux disease, infections, malignancy, collagen vascular diseases, hypersensitivity, and inflammatory bowel disease. There are no standardized protocols for the therapy of eosinophilic esophagitis. A variety of therapeutic approaches including acid suppression, dietary modifications, topical corticosteroids and endoscopic dilation can be used alone or in combination.

Keywords: Eosinophilic esophagitis, Dysphagia, Endoscopic dilation, Reflux, Gastro esophageal reflux disease