Prevalence of celiac disease in Iranian children with idiopathic short stature

doi:10.3748/wjg.14.7376

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2008; 14(48): 7376-7380
Published online Dec 28, 2008. doi: 10.3748/wjg.14.7376

Prevalence of celiac disease in Iranian children with idiopathic short stature

Jalal Hashemi, Eskandar Hajiani, HBB Shahbazin, Rahim Masjedizadeh, Navab Ghasemi

Jalal Hashemi, Eskandar Hajiani, Rahim Masjedizadeh, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran

HBB Shahbazin, Division of Endocrinology and Diabetes center, Department of Internal Medicine, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran

Navab Ghasemi, Department of Internal Medicine, Ahwaz Jundishapur University of Medical Sciences, Golestan Hospital, Ahwaz, Iran

Supported by A Grant from the Ahwaz Jondishapoor University of Medical Science, Ahwaz, Iran

Correspondence to: Eskandar Hajiani, Division of Gastro-enterology and Hepatology, Department of Internal Medicine, Ahwaz Jundishapur University of Medical Sciences, Golestan Hospital, PO Box 89, Ahwaz, Iran. ehajiani@ajums.ac.ir

Telephone: +98-611-5530222 Fax: +98-611-3340074

Received: February 2, 2007
Revised: September 1, 2008
Accepted: September 8, 2008
Published online: December 28, 2008

Abstract

AIM: To determine the prevalence of celiac disease (CD) in children with idiopathic short stature (ISS) and the diagnostic value of immunoglobulin (Ig) A G antigliadin antibodies (AGA) and transglutaminase (TTG) antibodies for CD.

METHODS: A total of 104 children (49 male, 55 female) with ISS without a specific etiology were studied. Extensive endocrine investigations had shown no abnormalities in any subject. Anthropometric parameters and IgA AGA and IgA TTG antibodies were evaluated in this study group. These antibodies were measured by enzyme-linked immunosorbent assay. All patients were referred for an endoscopic intestinal biopsy. The biopsy samples were classified according to revised Marsh criteria (UEGW 2001).

RESULTS: We detected positive IgA TTG antibodies in 36 and IgA AGA in 35 of these patients. Thirty one IgA TTG antibody positive and 28 IgA AGA positive subjects showed histological abnormalities compatible with celiac disease (33.6%). Sensitivity, specificity, positive predictive value (PPV) and negative predictive value for IgA AGA were found to be 80%, 88.4%, 77.8% and 89.7%, respectively. Sensitivity, specificity and PPV for IgA TTG antibodies were 88.6%, 94.2% and 88.6%, respectively.

CONCLUSION: We conclude that the prevalence of celiac disease is high in patients with ISS and it is important to test all children with ISS for celiac disease by measuring serologic markers and performing an intestinal biopsy.

Keywords: Celiac disease, Growth disorders, Transglu-taminases, Antibodies, Gliadin