Choe YM, Lee KY, Oh CA, Lee JB, Choi SK, Hur YS, Kim SJ, Cho YU, Ahn SI, Hong KC, Shin SH, Kim KR. Risk factors affecting pancreatic fistulas after pancreaticoduodenectomy. World J Gastroenterol 2008; 14(45): 6970-6974 [PMID: 19058333 DOI: 10.3748/wjg.14.6970]
Corresponding Author of This Article
Seung-Ik Ahn, MD, Department of Surgery, Inha University Hospital, 7-206, 3 Ga Shinheung-dong, Jung-Gu, Incheon 400-711, South Korea. siahn@inha.ac.kr
Article-Type of This Article
Rapid Communication
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World J Gastroenterol. Dec 7, 2008; 14(45): 6970-6974 Published online Dec 7, 2008. doi: 10.3748/wjg.14.6970
Risk factors affecting pancreatic fistulas after pancreaticoduodenectomy
Yun-Mee Choe, Keon-Young Lee, Cheong-Ah Oh, Joung-Bum Lee, Sun Keun Choi, Yoon-Seok Hur, Sei-Joong Kim, Young Up Cho, Seung-Ik Ahn, Kee-Chun Hong, Seok-Hwan Shin, Kyung-Rae Kim
Yun-Mee Choe, Keon-Young Lee, Cheong-Ah Oh, Joung-Bum Lee, Sun Keun Choi, Yoon-Seok Hur, Sei-Joong Kim, Young Up Cho, Seung-Ik Ahn, Kee-Chun Hong, Seok-Hwan Shin, Kyung-Rae Kim, Department of Surgery, Inha University Hospital, Incheon 400-711, South Korea
Author contributions: Choe YM and Ahn SI contributed equally to this work; Choe YM, Lee KY, Oh CA, Lee JB, Choi SK and Hur YS designed the research; Choe YM, Lee KY, Oh CA, Lee JB, Choi SK, Hur YS, Kim SJ, Cho YU and Ahn SI performed the research; Hong KC, Shin SH and Kim KR contributed new reagents/analytic tools; Oh CA and Lee JB analyzed the data; Choe YM, Lee KY, Lee JB and Ahn SI wrote the paper.
Supported by Inha University Research Funds of 2007
Correspondence to: Seung-Ik Ahn, MD, Department of Surgery, Inha University Hospital, 7-206, 3 Ga Shinheung-dong, Jung-Gu, Incheon 400-711, South Korea. siahn@inha.ac.kr
Telephone: +82-32-8902250 Fax: +82-32-8903097
Received: July 15, 2008 Revised: November 12, 2008 Accepted: November 19, 2008 Published online: December 7, 2008
Abstract
AIM: To analyze the risk factors of pancreatic leakage after pancreaticoduodenectomy.
METHODS: We retrospectively reviewed 172 consecutive patients who had undergone pancreatico-duodenectomy at Inha University Hospital between April 1996 and March 2006. We analyzed the pancreatic fistula rate according to the clinical characteristics, the pathologic and laboratory findings, and the anastomotic methods.
RESULTS: The incidence of developing pancreatic fistulas in patients older than 60 years of age was 21.7% (25/115), while the incidence was 8.8% (5/57) for younger patients; the difference was significant (P = 0.03). Patients with a dilated pancreatic duct had a lower rate of post-operative pancreatic fistulas than patients with a non-dilated duct (P = 0.001). Other factors, including clinical features, anastomotic methods, and pathologic diagnosis, did not show any statistical difference.
CONCLUSION: Our study demonstrated that pancreatic fistulas are related to age and a dilated pancreatic duct. The surgeon must take these risk factors into consideration when performing a pancre-aticoduodenectomy.
