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©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Nov 14, 2008; 14(42): 6575-6577
Published online Nov 14, 2008. doi: 10.3748/wjg.14.6575
Published online Nov 14, 2008. doi: 10.3748/wjg.14.6575
Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: Case report with molecular analysis
Marta Barisella, Antonino Carbone, Anathomic Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 20133, Italy
Andrea Lampis, Federica Perrone, Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 20133, Italy
Author contributions: Barisella M wrote the paper and performed immunohistochemical evaluation; Lampis A, Perrone F performed molecular analyses; Carbone A coordinated study.
Supported by A grant from the Ministero della Salute, Rome, within the framework of the Progetto Integrato Oncologia-Advanced Molecular Diagnostics “Multidimensional characterization of solid tumors”; and Lega Italiana per la Lotta Contro i Tumori, sezione Milanese
Correspondence to: Dr. Marta Barisella, Anathomic Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, Milano 20133, Italy. marta.barisella@istitutotumori.mi.it
Telephone: +39-2-23902413 Fax: +39-2-23902198
Received: August 1, 2008
Revised: September 11, 2008
Accepted: September 18, 2008
Published online: November 14, 2008
Revised: September 11, 2008
Accepted: September 18, 2008
Published online: November 14, 2008
Abstract
Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma.
Keywords: Clear cell carcinoma, Colon carcinoma, Beta-catenin, KRAS, Molecular analysis