Korkolis DP, Apostolaki K, Aggeli C, Plataniotis G, Gontikakis E, Volanaki D, Sebastiadou M, Dimitroulopoulos D, Xinopoulos D, Zografos GN, Vassilopoulos PP. Solitary fibrous tumor of the liver expressing CD34 and vimentin: A case report. World J Gastroenterol 2008; 14(40): 6261-6264 [PMID: 18985821 DOI: 10.3748/wjg.14.6261]
Corresponding Author of This Article
Dimitris P Korkolis, MD, PhD, Department of Surgical Oncology, Hellenic Anticancer Institute, “Saint Savvas” Hospital, 22 Socratous Street, 1st Floor, Kifissia, 14561 Athens, Greece. dkorkolis_2000@yahoo.com
Article-Type of This Article
Case Report
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World J Gastroenterol. Oct 28, 2008; 14(40): 6261-6264 Published online Oct 28, 2008. doi: 10.3748/wjg.14.6261
Solitary fibrous tumor of the liver expressing CD34 and vimentin: A case report
Dimitris P Korkolis, Katerina Apostolaki, Chrysanthi Aggeli, George Plataniotis, Emmanuel Gontikakis, Dimitra Volanaki, Maria Sebastiadou, Dimitris Dimitroulopoulos, Dimitris Xinopoulos, George N Zografos, Perikles P Vassilopoulos
Dimitris P Korkolis, Chrysanthi Aggeli, George Plataniotis, Emmanuel Gontikakis, Dimitra Volanaki, Perikles P Vassilopoulos, Department of Surgical Oncology, Hellenic Anticancer Institute, “Saint Savvas” Hospital, Athens, Greece
Katerina Apostolaki, Maria Sebastiadou, Department of Surgical Pathology, Hellenic Anticancer Institute, “Saint Savvas” Hospital, Athens, Greece
Dimitris Dimitroulopoulos, Dimitris Xinopoulos, Department of Gastroenterology, Hellenic Anticancer Institute, “Saint Savvas” Hospital, Athens, Greece
George N Zografos, Department of Surgery, General Hospital of Athens, “G. Gennimatas”, Athens, Greece
Author contributions: Korkolis DP and Aggeli C designed the research; Korkolis DP, Aggeli C, Plataniotis G, Gontikakis E, Volanaki D, Vassilopoulos PP performed the research; Apostolaki K and Sebastiadou M performed the data analysis; Dimitroulopoulos D and Xinopoulos D contributed to the interpretation of data and Zografos GN had important intellectual contributions.
Correspondence to: Dimitris P Korkolis, MD, PhD, Department of Surgical Oncology, Hellenic Anticancer Institute, “Saint Savvas” Hospital, 22 Socratous Street, 1st Floor, Kifissia, 14561 Athens, Greece. dkorkolis_2000@yahoo.com
Telephone: +30-210-8083743 Fax: +30-210-8012689
Received: June 28, 2008 Revised: October 16, 2008 Accepted: October 23, 2008 Published online: October 28, 2008
Abstract
A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported. An 82-year-old female presented with left upper abdominal discomfort, a firm mass on palpation, and imaging studies revealed a large tumor, 15 cm in diameter, arising from the left lobe of the liver. A formal left hepatectomy was performed. Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma. Immunohistochemistry disclosed diffuse CD34 and positive vimentin, supporting the diagnosis of a benign SFT. The patient remained well 21 months after surgery. SFT of the liver is a very rare neoplasm of mesenchymal origin. In most cases it is a benign lesion, although some may have malignant histological features and recur locally or metastasize. With less than 30 reported cases in the literature, little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy. Complete surgical resection remains the cornerstone of its treatment.
