Li YM, Yang HZ, Guan WB, Ke QS, Dai M, Xie HP, Zhang SJ. Therapeutic effect of traditional Chinese medicine on coagulation disorder and accompanying intractable jaundice in hepatitis B virus-related liver cirrhosis patients. World J Gastroenterol 2008; 14(39): 6060-6064 [PMID: 18932286 DOI: 10.3748/wjg.14.6060]
Corresponding Author of This Article
Hong-Zhi Yang, Department of TCM, The Third Affiliated Hospital of Sun Yat-Sen University, 600# Tianhe Road, Guangzhou 510630, Guangdong Province, China. hzyang1960@163.com
Article-Type of This Article
Rapid Communication
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World J Gastroenterol. Oct 21, 2008; 14(39): 6060-6064 Published online Oct 21, 2008. doi: 10.3748/wjg.14.6060
Therapeutic effect of traditional Chinese medicine on coagulation disorder and accompanying intractable jaundice in hepatitis B virus-related liver cirrhosis patients
Yang-Mei Li, Hong-Zhi Yang, Wei-Bing Guan, Qian-Shan Ke, Min Dai, He-Ping Xie, Department of TCM, The Third Affiliated Hospital of Sun Yat-Sen University, 600# Tianhe Road, Guangzhou 510630, Guangdong Province, China
Shi-Jun Zhang, Department of TCM, The First Affiliated Hospital of Sun Yat-Sen University, 58# Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China
Author contributions: Li YM and Yang HZ contributed equally to this work, designed and overviewed the research; Li YM, Zhang SJ and Xie HP analyzed the data; Li YM, Ke QS, Guan WB and Dai M performed the research; Li YM wrote the paper.
Supported by Science and Technology Agency of Guangdong Province, NO. 2008B030301041
Correspondence to: Hong-Zhi Yang, Department of TCM, The Third Affiliated Hospital of Sun Yat-Sen University, 600# Tianhe Road, Guangzhou 510630, Guangdong Province, China. hzyang1960@163.com
Telephone: +86-13318815024 Fax: +86-20-85253336
Received: June 26, 2008 Revised: August 5, 2004 Accepted: August 12, 2008 Published online: October 21, 2008
Abstract
AIM: To observe the therapeutic effects of new traditional Chinese medicine (TCM) therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients.
METHODS: Using stratified random sampling according to fibrinogen (Fib) levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by “nourishing yin, cooling blood and invigorating blood circulation” and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared.
RESULTS: The prothrombin time (PT) was shorter and the fibrinogen (Fib) level was higher in the research group than in the control group (Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and ≤ 1.0 g/L). The total bilirubin (TBIL) level was significantly lower in the research group than in the control group, except for the subgroup of FIB ≤ 1.0 g/L.
CONCLUSION: TCM therapy can improve coagulation function and decrease TBIL.
