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©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Aug 28, 2008; 14(32): 5078-5083
Published online Aug 28, 2008. doi: 10.3748/wjg.14.5078
Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males
Chang-Ming Gao, Toshiro Takezaki, Jian-Zhong Wu, Xiao-Mei Zhang, Hai-Xia Cao, Jian-Hua Ding, Yan-Ting Liu, Su-Ping Li, Jia Cao, Keitaro Matsuo, Nobuyuki Hamajima, Kazuo Tajima
Chang-Ming Gao, Jian-Zhong Wu, Xiao-Mei Zhang, Hai-Xia Cao, Jian-Hua Ding, Yan-Ting Liu, Su-Ping Li, Division of Epidemiology, Jiangsu Provincial Institute of Cancer Research, 42 Baiziting, Nanjing 210009, Jiangsu Province, China
Toshiro Takezaki, Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan
Jia Cao, Hygiene Toxicology Department, Third Military Medical University Preventive medicine college, 30 Gaotanyan Avenue, Shapingba District, Chongqing 400038, China
Keitaro Matsuo, Kazuo Tajima, Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
Nobuyuki Hamajima, Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University School of Medicine, Nagoya 466-8550, Japan
Author contributions: Gao CM and Tajima K contributed equally to this work; Gao CM, Tajima K, Cao Jia, Takezaki T, Matsuo K and Hamajima N designed research; Gao CM, Ding JH and Wu JZ performed research; Wu JZ, Cao HX and Zhang XM contributed experimental analysis; Liu YT and Li SP collected Environmental data; Gao CM analyzed data; and Gao CM and Tajima K wrote the paper.
Supported by (in part) A Grant-in Aid for International Scientific Research; Special Cancer Research from the Ministry of Education, Science, Sports, Culture and Technology of Japan, No. 11137311; Major International (Regional) Joint Research Projects from the National Natural Science Foundation of China (NSFC), No. 30320140461
Correspondence to: Chang-Ming Gao, Division of Epidemi-ology, Jiangsu Provincial Institute of Cancer Research, 42 Baiziting, Nanjing 210009, China. gaocm888@126.com
Telephone: +86-25-83283486 Fax: +86-25-83641062
Received: May 22, 2008
Revised: August 11, 2008
Accepted: August 18, 2008
Published online: August 28, 2008
AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males.
METHODS: A case-control study was conducted in 190 cases and 223 population-based controls. ADH2 Arg47His (G-A) and ALDH2 Glu487Lys (G-A) genotypes were identified by PCR and denaturing high-performance liquid chromatography (DHPLC). Information on smoking and drinking was collected and odds ratio (OR) was estimated.
RESULTS: The ADH2 A/A and ALDH2 G/G genotypes showed moderately increased CRC risk. The age- and smoking-adjusted OR for ADH2 A/A relative to G/A and G/G was 1.60 (95% CI=1.08-2.36), and the adjusted OR for ALDH2 G/G relative to G/A and A/A was 1.79 (95% CI=1.19-2.69). Significant interactions between ADH2, ALDH2 and drinking were observed. As compared to the subjects with ADH2 G and ALDH2 A alleles, those with ADH2 A/A and ALDH2 G/G genotypes had a significantly increased OR (3.05, 95% CI= 1.67-5.57). The OR for CRC among drinkers with the ADH2 A/A genotype was increased to 3.44 (95% CI= 1.84-6.42) compared with non-drinkers with the ADH2 G allele. The OR for CRC among drinkers with the ALDH2 G/G genotype was also increased to 2.70 (95% CI= 1.57-4.66) compared with non-drinkers with the ALDH2 A allele.
CONCLUSION: Polymorphisms of the ADH2 and ALDH2 genes are significantly associated with CRC risk. There are also significant gene-gene and gene-environment interactions between drinking and ADH2 and ALDH2 polymorphisms regarding CRC risk in Chinese males.
