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World J Gastroenterol. Jul 28, 2008; 14(28): 4558-4561
Published online Jul 28, 2008. doi: 10.3748/wjg.14.4558
Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis
Li-Hui Deng, Ping Xue, Qing Xia, Xiao-Nan Yang, Mei-Hua Wan
Li-Hui Deng, Ping Xue, Qing Xia, Xiao-Nan Yang, Mei-Hua Wan, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Deng LH, Xue P and Xia Q designed the research protocol; Deng LH, Xue P, Yang XN and Wan MH performed the research; Deng LH and Xue P collected and analyzed the data; Deng LH, Xue P and Xia Q wrote the paper.
Correspondence to: Qing Xia, Professor, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. xiaqing@medmail.com.cn
Telephone: +86-28-85423373
Fax: +86-28-85423028
Received: May 22, 2008
Revised: June 23, 2008
Accepted: June 30, 2008
Published online: July 28, 2008
Abstract

AIM: To investigate the effect of admission hypertriglyceridemia (HTG) on the episodes of severe acute pancreatitis (SAP).

METHODS: One hundred and seventy-six patients with SAP were divided into HTG group (n = 45) and control group (n = 131) according to admission triglyceride (TG) ≥ 5.65 mmol/L and < 5.65 mmol/L, respectively. Demographics, etiology, underlying diseases, biochemical parameters, Ranson’ s score, acute physiology and chronic heath evaluation II (APACHE II) score, Balthazar’s computed tomography (CT) score, complications and mortality were compared. Correlation between admission TG and 24-h APACHE II score was analyzed.

RESULTS: SAP patients with HTG were younger (40.8 ± 9.3 years vs 52.6 ± 13.4 years, P < 0.05) with higher etiology rate of overeating, high-fat diet (40.0% vs 14.5%, P < 0.05) and alcohol abuse (46.7% vs 23.7%, P < 0.01), incidence rate of hypocalcemia (86.7% vs 63.4%, P < 0.01) and hypoalbuminemia (84.4% vs 60.3%, P < 0.01), 24-h APACHE II score (13.6 ± 5.7 vs 10.7 ± 4.6, P < 0.01) and admission serum glucose (17.7 ± 7.7 vs 13.4 ± 6.1, P < 0.01), complication rate of renal failure (51.1% vs 16.8%, P < 0.01), shock (37.9% vs 14.5%, P < 0.01) and infection (37.4% vs 18.3%, P < 0.01) and mortality (13.1% vs 9.1%, P < 0.01). Logistic regression analysis showed a positive correlation between admission TG and 24-h APACHE II score (r = 0 .509, P = 0.004).

CONCLUSION: The clinical features of SAP patients with HTG are largely consistent with previous studies. HTG aggravates the episodes of SAP.

Keywords: Clinical study; Hypertriglyceridemia; Severe acute pancreatitis; Clinical features; Outcome