Hirano Y, Hara T, Nozawa H, Oyama K, Ohta N, Omura K, Watanabe G, Niwa H. Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach. World J Gastroenterol 2008; 14(20): 3269-3272 [PMID: 18506939 DOI: 10.3748/wjg.14.3269]
Corresponding Author of This Article
Yasumitsu Hirano, MD, PhD, Department of General and Cardiothoracic Surgery, Kanazawa University Graduate School of Medical Science 13-1, Takara-machi, Kanazawa 920-8641, Japan. yasumitsuhira@yahoo.co.jp
Article-Type of This Article
Case Report
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Yasumitsu Hirano, Kenji Omura, Go Watanabe, Department of General and Cardiothoracic Surgery, Kanazawa University Graduate school of Medical Science 13-1, Takara-machi, Kanazawa 920-8641, Japan
Takuo Hara, Hiroshi Nozawa, Kaeko Oyama, Naohiro Ohta, Department of Surgery, Kouseiren Takaoka Hospital 5-10, Eiraku-chou, Takaoka 933-8555, Japan
Hideki Niwa, Department of Pathology, Kouseiren Takaoka Hospital 5-10, Eiraku-chou, Takaoka 933-8555, Japan
Author contributions: Hirano Y, Hara T, Nozawa H, Oyama K and Ohta N contributed equally to this case; Niwa H contributed to pathological diagnosis; and Hirano Y, Hara T, Omura K and Watanabe G wrote the paper.
Correspondence to: Yasumitsu Hirano, MD, PhD, Department of General and Cardiothoracic Surgery, Kanazawa University Graduate School of Medical Science 13-1, Takara-machi, Kanazawa 920-8641, Japan. yasumitsuhira@yahoo.co.jp
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Received: October 24, 2007 Revised: April 4, 2008 Accepted: April 11, 2008 Published online: May 28, 2008
Abstract
We described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. An 85-year-old man visited our hospital because of appetite loss. Gastric fiberscopy revealed a large tumor occupying the cardial region and anterior wall of the gastric body. The patient underwent total gastrectomy with lymphnode dissection and partial resection of the liver. Choriocarcinoma, small cell carcinoma and tubular adenocarcinoma existed in the gastric tumor. The choriocarcinomatous foci contained cells positive for beta-subunit of human chorionic gonadotropin (B-hCG) and human placental lactogen mainly in syncytiotrophoblastic cells. The small cell carcinomatous foci contained cells positive for synaptophysin, neuron-specific enolase (NSE), and chromogranin A. The prognosis for gastric adenocarcinoma with choriocarcinoma and neuroendocrine cell carcinoma is exceedingly poor. This patient died about 2 mo after the first complaint from hepatic failure. This is the first reported case of gastric cancer with these three pathological features.
