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©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Apr 28, 2008; 14(16): 2596-2598
Published online Apr 28, 2008. doi: 10.3748/wjg.14.2596
Published online Apr 28, 2008. doi: 10.3748/wjg.14.2596
Concomitant autoimmune and genetic pancreatitis leads to severe inflammatory conditions
Jean Louis Frossard, Jean Marc Dumonceau, Catherine Pastor, Laurent Spahr, Antoine Hadengue, Division de Gastroentérologie et Hépatologie, Geneva University Hospital, Geneva 1205, Switzerland
Author contributions: Frossard JL and Spahr L contributed equally; Dumonceau JM, Frossard JL and Pastor C analyzed and collected data; Frossard JL and Hadengue A wrote the paper.
Correspondence to: Jean Louis Frossard, MD, Division de Gastroentérologie, Hôpitaux Universitaires de Genève, Geneva 1205, Switzerland. jean-louis.frossard@hcuge.ch
Telephone: +41-22-3729340
Fax: +41-22-3729366
Received: November 15, 2007
Revised: February 29, 2008
Published online: April 28, 2008
Revised: February 29, 2008
Published online: April 28, 2008
Abstract
Chronic pancreatitis characterized by an early onset should be extensively investigated including the search for a mutation of the PRSS1, SPINK-1 or CFTR genes and potential features of autoimmune pancreatitis. We here describe a case of chronic pancreatitis with an onset at a very young age in which a mutation of the PRSS1 and several features of autoimmune pancreatitis were identified.
Keywords: Chronic pancreatitis, Genetics, Autoimmune pancreatitis, SPINK-1, CFTR, PRSS1