Zhou YM, Yang JM, Li B, Yin ZF, Xu F, Wang B, Liu P, Li ZM. Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein. World J Gastroenterol 2008; 14(14): 2251-2254 [PMID: 18407604 DOI: 10.3748/wjg.14.2251]
Corresponding Author of This Article
Jia-Mei Yang, MD, Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China. yjm.1952@yahoo.com.cn
Article-Type of This Article
Rapid Communication
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World J Gastroenterol. Apr 14, 2008; 14(14): 2251-2254 Published online Apr 14, 2008. doi: 10.3748/wjg.14.2251
Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein
Yan-Ming Zhou, Jia-Mei Yang, Bin Li, Zheng-Feng Yin, Feng Xu, Bin Wang, Peng Liu, Zhi-Min Li
Yan-Ming Zhou, Bin Li, Zhi-Min Li, Department of Hepato-Biliary-Pancreato-Vascular Surgery, The First Xiamen Hospital, Fujian Medical University, Xiamen 361003, Fujian Province, China
Jia-Mei Yang, Feng Xu, Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
Zheng-Feng Yin, Bin Wang, Peng Liu, Molecular Oncology Research Laboratory, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
Author contributions: Zhou YM and Yang JM designed the study; Li B, Yin ZF, Xu F, and Wang B analyzed data; Zhou YM and Li ZM wrote the paper.
Correspondence to: Jia-Mei Yang, MD, Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China. yjm.1952@yahoo.com.cn
Telephone: +86-21-25070808
Fax: +86-21-65562400
Received: January 10, 2007 Revised: February 28, 2008 Published online: April 14, 2008
Abstract
AIM: To explore clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with positive serum a-fetoprotein (AFP).
METHODS: One hundred and thirty one patients who underwent surgical dissection for pathologically confirmed ICC were divided into a positive AFP (> 20 ng/mL) group (n = 32) and a negative AFP group (n = 99), whose clinicopathologic features were analyzed and compared.
RESULTS: The positive rate of HBsAg and liver cirrhosis of the positive AFP group was higher than that of the negative AFP group, while the positive rate of CA19-9 (> 37 U/mL) and the lymph node metastasis rate was lower.
CONCLUSION: ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma.
