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Kilicoglu B, Kismet K, Kilicoglu SS, Erel S, Gencay O, Sorkun K, Erdemli E, Akhan O, Akkus MA, Sayek I. Effects of honey as a scolicidal agent on the hepatobiliary system. World J Gastroenterol 2008; 14(13): 2085-2088 [PMID: 18395911 DOI: 10.3748/wjg.14.2085]
World J Gastroenterol. Apr 7, 2008; 14(13): 2085-2088 Published online Apr 7, 2008. doi: 10.3748/wjg.14.2085
Effects of honey as a scolicidal agent on the hepatobiliary system
Bulent Kilicoglu, Kemal Kismet, Sibel Serin Kilicoglu, Serap Erel, Omur Gencay, Kadriye Sorkun, Esra Erdemli, Okan Akhan, Mehmet Ali Akkus, Iskender Sayek
Bulent Kilicoglu, Kemal Kismet, Serap Erel, Mehmet Ali Akkus, Department of General Surgery, Ankara Training and Research Hospital, Ankara 06340, Turkey
Sibel Serin Kilicoglu, Department of Histology-Embryology, Ufuk University, Ankara 06340, Turkey
Omur Gencay, Kadriye Sorkun, Department of Biology, Faculty of Science, Hacettepe University, Ankara 06340, Turkey
Esra Erdemli, Department of Histology-Embryology, Ankara University, Ankara 06340, Turkey
Okan Akhan, Department of Radiology, Hacettepe University, Ankara 06340, Turkey
Iskender Sayek, Department of General Surgery, Hacettepe University, Ankara 06340, Turkey
Author contributions: Kilicoglu B and Kismet K contributed equally to this work, Kilicoglu SS and Erdemli E performed histological examination, Gencay O and Sorkun K analyzed honey, Akhan O performed radiological examination, Akkus MA and Erel S analyzed data; and Sayek I, Kismet K and Kilicoglu B wrote the paper.
Correspondence to: Bulent Kilicoglu, Ankara Training and Research Hospital Ulucanlar, Ankara 06340, Turkey. kilicoglubulent@yahoo.com
Telephone: +90-312-5953449
Fax: +90-312-3633697
Received: December 26, 2007 Revised: February 27, 2008 Published online: April 7, 2008
Abstract
AIM: To examine the effects of 10% diluted honey, which has been shown to be scolicidal, on the liver and biliary system and determine whether it could be used as a scolicidal agent in the presence of biliary-cystic communication.
METHODS: Thirty Wistar-Albino rats were divided into two groups. Honey with 10% dilution in the study group and 0.9% saline (NaCl) in the control group were injected into the common bile ducts of rats through a 3-mm duodenotomy. The animals were sacrificed 6 mo after the procedure. Histopathological, biochemical, and radiological examinations were performed for evaluation of side effects.
RESULTS: At the end of the sixth month, liver function tests were found to be normal in both groups. The tissue samples of liver and ductus choledochus of the honey group showed no histomorphologic difference from the control group. No stricture on the biliary tree was detected on the retrograde cholangiograms.
CONCLUSION: According to these results, we concluded that 10% diluted honey could be used as scolicidal agent safely in the presence of biliary-cystic communication.
