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World J Gastroenterol. Mar 21, 2008; 14(11): 1643-1645
Published online Mar 21, 2008. doi: 10.3748/wjg.14.1643
Complications of collagenous colitis
Hugh James Freeman
Hugh James Freeman, Department of Medicine (Gastroen-terology), University of British Columbia, Vancouver V6T 1W5, Canada
Correspondence to: Dr. Hugh James Freeman, MD, FRCPC, FACP, Department of Medicine (Gastroenterology), University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada. hugfree@shaw.ca
Telephone: +1-604-8227216
Fax: +1-604-8227236
Received: December 19, 2007
Revised: February 15, 2008
Published online: March 21, 2008
Abstract

Microscopic forms of colitis have been described, including collagenous colitis. This disorder generally has an apparently benign clinical course. However, a number of gastric and intestinal complications, possibly coincidental, may develop with collagenous colitis. Distinctive inflammatory disorders of the gastric mucosa have been described, including lymphocytic gastritis and collagenous gastritis. Celiac disease and collagenous sprue (or collagenous enteritis) may occur. Colonic ulceration has been associated with use of nonsteroidal anti-inflammatory drugs, while other forms of inflammatory bowel disease, including ulcerative colitis and Crohn’s disease, may evolve from collagenous colitis. Submucosal “dissection”, colonic fractures or mucosal tears and perforation from air insufflation during colonoscopy may occur and has been hypothesized to be due to compromise of the colonic wall from submucosal collagen deposition. Similar changes may result from increased intraluminal pressure during barium enema contrast studies. Finally, malignant disorders have also been reported, including carcinoma and lymphoproliferative disease.

Keywords: Colonic fractures; Colonic perforation; Celiac disease; Collagenous gastritis; Collagenous sprue; Cat scratch colon; Colon cancer; Microscopic colitis