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World J Gastroenterol. Feb 21, 2007; 13(7): 1119-1122
Published online Feb 21, 2007. doi: 10.3748/wjg.v13.i7.1119
H pylori are associated with chronic cholecystitis
Dong-Feng Chen, Lu Hu, Ping Yi, Wei-Wen Liu, Dian-Chun Fang, Hong Cao
Dong-Feng Chen, Lu Hu, Ping Yi, Wei-Wen Liu, Dian-Chun Fang, Hong Cao, Department of Gastroenterology, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 39970039
Correspondence to: Dr. Dong-Feng Chen, Department of Gastroenterology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. dfchen9@hotmail.com
Telephone: +86-23-68757362 Fax: +86-23-68813806
Received: August 5, 2005
Revised: December 3, 2006
Accepted: January 23, 2007
Published online: February 21, 2007
Abstract

AIM: To study whether H pylori are associated with chronic cholecystitis.

METHODS: The subjects were divided into three groups: H pylori-infected cholecystitis group, H pylori-negative cholecystitis group and control group. Pathologic changes of the gallbladder were observed by optic and electronic microscopes and the levels of interleukin-1, 6 and 8 (IL-1, 6 and 8) were detected by radioimmunoassay.

RESULTS: Histological evidence of chronic cholecystitis including degeneration, necrosis, inflammatory cell infiltration, were found in the region where H pylori colonized. Levels of IL-1, 6 and 8 in gallbladder mucosa homogenates were significantly higher in H pylori-infected cholecystitis group than those in H pylori-negative cholecystitis group and control group.

CONCLUSION: H pylori infection may be related to cholecystitis.

Keywords: H pylori, Chronic cholecystitis, Interleukin, Colonization, Gallbladder mucosa