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©2007 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2007; 13(42): 5598-5604
Published online Nov 14, 2007. doi: 10.3748/wjg.v13.i42.5598
Published online Nov 14, 2007. doi: 10.3748/wjg.v13.i42.5598
Pouchitis
En-Da Yu, Department of Colorectal Surgery, Shanghai Changhai Hospital, Shanghai 200438, China
Zhuo Shao, Department of Biliary Surgery, Eastern Hepatobiliary Hospital, Shanghai 200438, China
Bo Shen, Digestive Disease Center, Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: All authors contributed equally to the work.
Supported by a grant from National Institutes of Health, No.R03 DK 067275 and a grant from Broad Medical Research Program of Broad Foundation
Correspondence to: Bo Shen, MD, Department of Gastroenterology/Hepatology-Desk A30, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, United States. shenb@ccf.org
Telephone: +1-216-4449252 Fax: +1-216-4446305
Received: July 11, 2007
Revised: July 31, 2007
Accepted: August 17, 2007
Published online: November 14, 2007
Revised: July 31, 2007
Accepted: August 17, 2007
Published online: November 14, 2007
Abstract
While restorative proctocolectomy with ileal pouch-anal anastomosis has significantly improved the quality of life in patients with underlying ulcerative colitis who require surgery, complications can occur. Pouchitis as the most common long-term complication represents a spectrum of disease processes ranging from acute, antibiotic-responsive type to chronic antibiotic-refractory entity. Accurate diagnosis using a combined assessment of symptoms, endoscopy and histology and the stratification of clinical phenotypes is important for treatment and prognosis the disease. The majority of patients respond favorably to antibiotic therapy. However, management of chronic antibiotic-refractory pouchitis remains a challenge.
Keywords: Classification, Complication, Ileal pouch, Inflammatory bowel disease, Restorative proctocolectomy