Randjelovic T, Filipovic B, Babic D, Cemerikic V, Filipovic B. Carcinosarcoma of the stomach: A case report and review of the literature. World J Gastroenterol 2007; 13(41): 5533-5536 [PMID: 17907304 DOI: 10.3748/wjg.v13.i41.5533]
Corresponding Author of This Article
Branka Filipovic, MD, MSc, Department of Gastroenterohepatology, Clinical and Hospital Center "Bezanijska Kosa", Autoput bb, Belgrade 11080, Serbia. branaf@bitsyu.net
Article-Type of This Article
Case Report
Open-Access Policy of This Article
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Tomislav Randjelovic, Department of Gastrointestinal Surgery, Clinical and Hospital Center "Bezanijska Kosa", Belgrade, Serbia
Branka Filipovic, Department of Gastroenterohepatology Clinical and Hospital Center "Bezanijska Kosa", Belgrade 11080, Serbia
Darko Babic, Department of Pathology, Clinical and Hospital Center "Bezanijska Kosa", Belgrade 11080, Serbia
Vesna Cemerikic, Laboratory for Histopathological and Cytological Diagnostics "Histolab", Belgrade 11080, Serbia
Branislav Filipovic, Institute of Anatomy, School of Medicine, University of Belgrade, Belgrade 11080, Serbia
Author contributions: All authors contributed equally to the work.
Correspondence to: Branka Filipovic, MD, MSc, Department of Gastroenterohepatology, Clinical and Hospital Center "Bezanijska Kosa", Autoput bb, Belgrade 11080, Serbia. branaf@bitsyu.net
Telephone: +381-11-3010700 Fax: +381-11-3010751
Received: May 20, 2007 Revised: June 18, 2007 Accepted: August 7, 2007 Published online: November 7, 2007
Abstract
Carcinosarcomas are rare, malignant, biphasic tumors. We report the case of a 62-year-old man with gastric carcinosarcoma, along with its clinical, macroscopic and histopathological features. Macroscopically, a specimen of deformed stomach was obtained that measured 200 mm × 150 mm × 100 mm. A 150 mm × 100 mm × 50 mm exophytic tumoral mass (Borrmann typeI) was found, which involved the posterior wall from the cardia to the antrum. Histopathologically, a mixed type of malignancy was revealed: an adenocarcinoma with intestinal metaplasia, with interposed fascicles of fusiform atypical cells and numerous large, rounded and oval cells. The tumor showed positive histochemistry for cytokeratin 18, epithelial membrane antigen, carcinoembryonic antigen, chromogranin A and vimentin. Liver metastases were diagnosed 8 mo postoperatively, and the patient died 4 mo later. A review of the available literature is also presented.
