Copyright
©2007 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2007; 13(39): 5288-5289
Published online Oct 21, 2007. doi: 10.3748/wjg.v13.i39.5288
Published online Oct 21, 2007. doi: 10.3748/wjg.v13.i39.5288
Portal vein thrombosis: Etiology and clinical outcome of cirrhosis and malignancy-related non-cirrhotic, non-tumoral extrahepatic portal venous obstruction
Pankaj Jain, Sandeep Nijhawan, Department of Gastro-enterology, Sms Medical College, Jaipur, India
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor Sandeep Nijhawan, Department of Gastroenterology, Sms Medical College, Jaipur, India. dr_nijhawan@yahoo.com
Telephone: +91-141-2722335 Fax: +91-141-2560994
Received: July 19, 2007
Revised: August 18, 2007
Accepted: September 14, 2007
Published online: October 21, 2007
Revised: August 18, 2007
Accepted: September 14, 2007
Published online: October 21, 2007
Abstract
The etiology and pathogenesis of portal vein thrombosis are unclear. Portal venous thrombosis presentation differs in cirrhotic and tumor-related versus non-cirrhotic and non-tumoral extrahepatic portal venous obstruction (EHPVO). Non-cirrhotic and non-tumoral EHPVO patients are young and present with well tolerated bleeding. Cirrhosis and tumor-related portal vein thrombosis patients are older and have a grim prognosis. Among the 118 patients with portal vein thrombosis, 15.3% had cirrhosis, 42.4% had liver malignancy (primary or metastatic), 6% had pancreatitis (acute or chronic), 5% had hypercoagulable state and 31.3% had idiopathy, 12% had hypercoagulable state in the EHPVO group.