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World J Gastroenterol. Sep 14, 2007; 13(34): 4626-4629
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4626
Matrix metalloproteinase-9-1562C>T polymorphism may increase the risk of lymphatic metastasis of colorectal cancer
Li-Li Xing, Zhen-Ning Wang, Li Jiang, Yong Zhang, Ying-Ying Xu, Juan Li, Yang Luo, Xue Zhang
Li-Li Xing, Zhen-Ning Wang, Yong Zhang, Ying-Ying Xu, Juan Li, Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Li Jiang, Yang Luo, Xue Zhang, Department of Medical Genomics of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: All authors contributed equally to the work.
Supported by Program for New Century Excellent Talents in University, NCET-06-0296
Correspondence to: Dr. Zhen-Ning Wang, Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. josieon826@yahoo.com.cn
Telephone: +86-24-83283556
Received: June 11, 2007
Revised: June 20, 2007
Accepted: June 23, 2007
Published online: September 14, 2007
Abstract

AIM: To explore the role of the matrix metalloproteinase-9 (MMP-9) polymorphism in colorectal cancer (CRC) in a northeast Chinese population.

METHODS: Genotyping of MMP-9-1562C>T and 279R>Q polymorphisms was carried out on blood samples from 137 colorectal cancer patients and 199 controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI).

RESULTS: The distribution of MMP-9 -1562C>T and 279 R>Q genotype was not significantly associated with the risk of CRC. However, the risk of llymph node metastasis of CRC was increased in patients with the -1562T allele (OR = 2.601; 95% CI = 1.160-5.835; P = 0.022). The frequency of MMP-9 279RR + RQ genotype was higher than the QQ genotype among CRC patients younger than sixty years old (OR = 0.102; 95% CI = 0.013-0.812; P = 0.012).

CONCLUSION: Our results indicated that the MMP-9-1562C>T polymorphism affects lymph node metastasis of CRC. In addition, the MMP-9 279R allele may lead to a younger age of onset of colorectal cancer.

Keywords: Matrix metalloproteinase-9, Polymorphisms, Colorectal cancer, Lymphatic node metastasis