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World J Gastroenterol. Aug 28, 2007; 13(32): 4340-4344
Published online Aug 28, 2007. doi: 10.3748/wjg.v13.i32.4340
Effect of vitamin E on oxidative stress status in small intestine of diabetic rat
A Shirpoor, MH Khadem Ansari, S Salami, F Ghaderi Pakdel, Y Rasmi
A Shirpoor, F Ghaderi Pakdel, Department of Physiology, Faculty of Medicine, Jaddeh Nazloo, Urmia, Iran
MH Khadem Ansari, S Salami, Y Rasmi, Department of Biochemistry, Faculty of Medicine, Jaddeh Nazloo, Urmia, Iran
Author contributions: All authors contributed equally to the work.
Correspondence to: A Shirpoor, Department of Physiology, Faculty of Medicine, Jaddeh Nazloo, Urmia, Iran. ashirpoor@yahoo.com
Telephone: +98-441-2770698 Fax: +98-441-2780801
Received: May 9, 2007
Revised: May 23, 2007
Accepted: May 28, 2007
Published online: August 28, 2007
Abstract

AIM: To investigate the effect of vitamin E on oxidative stress status in the small intestine of diabetic rats.

METHODS: Twenty-four male Wistar rats were randomly divided into three groups: Control (C), non-treated diabetic (NTD) and vitamin E-treated diabetic (VETD) groups. The increases in lipid peroxidation, protein oxidation and superoxide dismutase (SOD) in these three groups was compared after 6 wk.

RESULTS: There was no significant difference in catalase activity between NTD and control rats. Compared to NTD rats, the treatment with vitamin E significantly decreased lipid peroxidation and protein oxidation, and also increased catalase activity and SOD.

CONCLUSION: The results revealed the occurrence of oxidative stress in the small intestine of diabetic rats. Vitamin E, as an antioxidant, attenuates lipid peroxidation and protein oxidation, and increases antioxidant defense mechanism.

Keywords: Diabetes mellitus, Small intestine, Rat, Vitamin E, Oxidative stress