Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer

doi:10.3748/wjg.v13.i24.3354

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2007; 13(24): 3354-3358
Published online Jun 28, 2007. doi: 10.3748/wjg.v13.i24.3354

Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer

Hedayat Allah Hosseini, Ali Ahani, Hamid Galehdari, Ali Mohammad Froughmand, Masoud Hosseini, Abdolrahim Masjedizadeh, Mohammad Reza Zali

Hedayat Allah Hosseini, Abdolrahim Masjedizadeh, Biochemistry Department, Medical school, Ahwaz Jondishapoor University of Medical Science, Ahwaz, Iran

Ali Ahani, Masoud Hosseini, Biology Department, Shahid Beheshti University, Tehran, Iran.

Hamid Galehdari, Ali Muhammad Froughmand, Genetics Department, Shahid Chamran University, Ahwaz, Iran Mohammad Reza Zali, Research Center of Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Science, Tehran, Iran

Author contributions: All authors contributed equally to the work.

Supported by Research Center of Gastric and Liver Disease in Tehran Taleghani hospital

Correspondence to: Hedayat Allah Hosseini, Biochemistry Department, Ahwaz Jondishapoor University of Medical Science, Ahwaz, Iran. hosseini.h@aujums.ac.ir

Telephone: +98-61-13332036 Fax: +98-61-13332036

Received: December 25, 2006
Revised: January 20, 2007
Accepted: January 25, 2007
Published online: June 28, 2007

Abstract

AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.

METHODS: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma.

RESULTS: Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively.

CONCLUSION: A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.

Keywords: Loss of heterozygosity, Tumor suppressor genes, diffuse type of gastric cancer, STS marker, N-Acetyltransferase 2, Fez1