Magyari L, Faragó B, Bene J, Horvatovich K, Lakner L, Varga M, Figler M, Gasztonyi B, Mózsik G, Melegh B. No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn’s disease and ulcerative colitis in Hungarian population samples. World J Gastroenterol 2007; 13(15): 2205-2208 [PMID: 17465502 DOI: 10.3748/wjg.v13.i15.2205]
Corresponding Author of This Article
Dr. Béla Melegh, Professor of Medical Genetics and Pediatrics, Department of Medical Genetics and Child Development, University of Pécs, H-7624 Pécs, Szigeti 12, Hungary. bela.melegh@aok.pte.hu
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Rapid Communication
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World J Gastroenterol. Apr 21, 2007; 13(15): 2205-2208 Published online Apr 21, 2007. doi: 10.3748/wjg.v13.i15.2205
No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn’s disease and ulcerative colitis in Hungarian population samples
Lili Magyari, Bernadett Faragó, Judit Bene, Katalin Horvatovich, Lilla Lakner, Márta Varga, Mária Figler, Beáta Gasztonyi, Gyula Mózsik, Béla Melegh
Lili Magyari, Bernadett Faragó, Judit Bene, Katalin Horvatovich, Béla Melegh, Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary
Judit Bene, MTA PTE Clinical Genetics Research Group of the Hungarian Academy of Sciences at the University of Pécs, Pécs, Hungary
Lilla Lakner, Markusovszky Hospital, Department of Medicine and Gastroenterology, Szombathely, Hungary
Márta Varga, Réthy Pál Hospital, 3rd Department of Medicine and Gastroenterology, Békéscsaba, Hungary
Mária Figler, Gyula Mózsik, 1st Department of Medicine, School of Medicine, University of Pécs, Pécs, Hungary
Beáta Gasztonyi, Department of Gastroenterology, Zala County Hospital, Zalaegerszeg, Hungary
Author contributions: All authors contributed equally to the work.
Supported by the grants of Hungarian Science Foundation (OTKA T 049589), Hungarian Ministry of Health (ETT 497/2006), and by the National Office for Research and Technology, “Pazmany Peter” program, (RET-II 08/2005)
Correspondence to: Dr. Béla Melegh, Professor of Medical Genetics and Pediatrics, Department of Medical Genetics and Child Development, University of Pécs, H-7624 Pécs, Szigeti 12, Hungary. bela.melegh@aok.pte.hu
Telephone: +36-72-536427 Fax: +36-72-536427
Received: January 16, 2007 Revised: January 24, 2007 Accepted: January 31, 2007 Published online: April 21, 2007
Abstract
AIM: The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohn’s disease (CD) and ulcerative colitis (UC).
METHODS: A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism (SNP). The genotypes were determined by using PCR/RFLP test.
RESULTS: The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively.
CONCLUSION: The results of the current study show that carriage of the +49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.
