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World J Gastroenterol. Mar 7, 2006; 12(9): 1435-1438
Published online Mar 7, 2006. doi: 10.3748/wjg.v12.i9.1435
Crohn’s disease in adults: Observations in a multiracial Asian population
Ida Hilmi, YM Tan, KL Goh
Ida Hilmi, YM Tan, KL Goh, Division of Gastroenterology, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Correspondence to: Professor KL Goh, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. klgoh56@tm.net.my
Telephone: +603-79556936 Fax: +603-79556936
Received: March 4, 2005
Revised: May 1, 2005
Accepted: November 18, 2005
Published online: March 7, 2006

AIM: To determine the demography and clinical presentation of CD and secondly to determine any differences in the prevalence between the different ethnic groups in a multiracial Asian population.

METHODS: Patients with CD who were seen in 2001–2003 in the University of Malaya Medical Centre (UMMC) were enrolled in this study. Prevalence of disease was calculated for the group as a whole and by race with hospital admissions per ethnic group as the denominator.

RESULTS: Thirty-four patients were diagnosed to have CD. Basic demographic data of patients; male:female 17:17; mean age 29.1 years (±13.5 years); ethnic group: Malays 5 (14.7%), Chinese 12 (35.3%) and Indians 17 (50%). Twenty-six (76.5%) were diagnosed under the age of 40 and 8 (23.5%) were diagnosed over the age of 40. Location of the disease was as follows: ileocolonic 13 (38.2%), terminal ileum only 9 (26.5%), colon only 8 (23.5%), and upper gastrointestinal 4 (11.8%). Sixteen (47.1%) had penetrating disease, 9 (26.5%) had stricturing disease and 9 (26.5%) had non-penetrating and non-stricturing disease. The hospital admission prevalence of CD was 26.0 overall, Indians 52.6, Chinese 6.9, and Malays 9.3 per 105 admissions per ethnic group. The difference between Indians and Malays: [OR 5.67 (1.97, 17.53) P < 0.001] was statistically significant but not between the Indians and the Chinese [OR 1.95 (0.89, 4.35) P = 0.700]. The difference between the Chinese and the Malays was also not statistically significant. [OR 2.90 (0.95, 9.42) P = 0.063].

CONCLUSION: The clinical presentation of CD is similar to the Western experience. Although the overall prevalence is low, there appears to be a clear racial predominance among the Indians.

Keywords: Crohn’s disease, Multiracial Asian population, Racial differences