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World J Gastroenterol. Mar 7, 2006; 12(9): 1329-1335
Published online Mar 7, 2006. doi: 10.3748/wjg.v12.i9.1329
Role of cholecystokinin and central serotonergic receptors in functional dyspepsia
Andrew Seng Boon Chua, PWN Keeling, TG Dinan
Andrew Seng Boon Chua, Ipoh Gastro Centre, Ipoh, Malaysia
PWN Keeling, Department of Medicine, Trinity College Dublin, Ireland
TG Dinan, Departments of Psychiatry and Alimentary Phar-mabiotic Centre, University College Cork, Ireland
Correspondence to: Andrew Seng Boon Chua, Ipoh Gastro Centre, 31 Lebuhraya Taman Ipoh, Ipoh Garden South, 31400, Ipoh, Perak, Malaysia. andrewchua@myjaring.net
Telephone: +6-5-5458488 Fax: +6-5-5457488
Received: October 17, 2005
Revised: October 25, 2005
Accepted: November 18, 2005
Published online: March 7, 2006

Symptoms of functional dyspepsia are characterized by upper abdominal discomfort or pain, early satiety, postprandial fullness, bloating, nausea and vomiting. It is a chronic disorder, with symptoms more than 3 mo per year, and no evidence of organic diseases. Dysfunctional motility, altered visceral sensation, and psychosocial factors have all been identified as major pathophysiological mechanisms. It is believed that these pathophysiological mechanisms interact to produce the observed symptoms. Dyspepsia has been categorized into three subgroups based on dominant symptoms. Dysmotility-like dyspepsia describes a subgroup of patients whose symptom complex is usually related to a gastric sensorimotor dysfunction. The brain-gut peptide cholecystokinin (CCK) and serotonin (5-HT) share certain physiological effects. Both have been shown to decrease gastric emptying and affect satiety. Furthermore the CCK induced anorexia depended on serotonergic functions probably acting via central pathways. We believe that abnormalities of central serotonergic receptors functioning together with a hyper responsiveness to CCK or their interactions may be responsible for the genesis of symptoms in functional dyspepsia (FD).

Keywords: Functional dyspepsia, Cholecystokinin, Serotonin, Gastric emptying