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World J Gastroenterol. Dec 28, 2006; 12(48): 7753-7757
Published online Dec 28, 2006. doi: 10.3748/wjg.v12.i48.7753
Published online Dec 28, 2006. doi: 10.3748/wjg.v12.i48.7753
Mechanisms of regulation and function of G-protein-coupled receptor kinases
Wen Yang, Shi-Hai Xia, Department of Gastroenterology, Pancreas Center, Affiliated Hospital of Medical College of the Chinese People’s Armed Police Forces, Tianjin 300162, China
Supported by the National Natural Science Foundation of China, No. 30300465; Scientific Research Fund of Medical College of Chinese People’s Armed Police Forces, No. WY2002-19
Correspondence to: Shi-Hai Xia, MD, Department of Gastroenterology, Pancreas Center, Affiliated Hospital of Medical College of the Chinese People’s Armed Police Forces, Chenglinzhuang Road, Tianjin 300162, China. xshhcx@sina.com
Telephone: +86-22-60578765 Fax: +86-22-24370605
Received: October 20, 2006
Revised: October 28, 2006
Accepted: November 23, 2006
Published online: December 28, 2006
Revised: October 28, 2006
Accepted: November 23, 2006
Published online: December 28, 2006
Abstract
G-protein-coupled receptor kinases (GRKs) interact with the agonist-activated form of G-protein-coupled receptor (GPCR) to affect receptor phosphorylation and to initiate profound impairment of receptor signaling, or desensitization. GPCR forms the largest family of cell surface receptors, and defects in GRK function have the potential consequence to affect GPCR-stimulated biological responses in many pathological situations.
Keywords: G-protein-coupled receptor kinases, G-protein-coupled receptor, Signal, Transduction, Phosphorylation