Review
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World J Gastroenterol. Dec 14, 2006; 12(46): 7467-7471
Published online Dec 14, 2006. doi: 10.3748/wjg.v12.i46.7467
Treatment of hyperbilirubinemia with blood purification in China
Zhi-Jun Duan, Lei-Lei Li, Jia Ju, Zhi-Hong Gao, Gao-Hong He
Zhi-Jun Duan, Lei-Lei Li, Zhi-Hong Gao, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Jia Ju, Gao-Hong He, R&D Center of Membrane Science and Technology, Dalian University of Technology, Dalian 116012, Liaoning Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor Zhi-Jun Duan, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China. cathydoctor@yahoo.com
Telephone: +86-411-83635963-3081 Fax: +86-411-83632383
Received: August 10, 2006
Revised: October 15, 2006
Accepted: October 30, 2006
Published online: December 14, 2006
Abstract

The incidence of hyperbilirubinemia is high clinically, which is difficult to cure by medication, surgery or interventional therapies. Non-bioartificial liver is the main alternative in the blood purification for hyperbilirubinemia, which includes plasma exchange, hemoperfusion, hemodialysis, molecular adsorbent recycling system and so on. The research results and clinical experiences in China show that these methods are effective in lowering high levels of bilirubin with fewer side effects. The hyperbilirubinemias of different causes, with different complications or accompanying different diseases can be treated by different methods. Bioartificial liver, hybrid artificial liver support system and adsorbent membrane material have also been studied and their development in reducing hyperbilirubinemias has been achieved. This article gives a brief overview on the actuality and research improvement in blood purification for hyperbilirubinemia in China.

Keywords: Hyperbilirubinemia; Blood purification; Treatment; China; Review