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World J Gastroenterol. Dec 14, 2006; 12(46): 7460-7462
Published online Dec 14, 2006. doi: 10.3748/wjg.v12.i46.7460
Published online Dec 14, 2006. doi: 10.3748/wjg.v12.i46.7460
Functional significance of erythropoietin receptor on tumor cells
Kodetthoor B Udupa, Reynolds Institute on Aging, Department of Geriatrics, Physiology and Biophysics, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System 4300 West Seventh Street, Little Rock, AR, United States
Author contributions: All authors contributed equally to the work.
Correspondence to: Kodetthoor B Udupa, PhD, Medical Research, Central Arkansas Veterans Healthcare System, 4300 West Seventh Street, Little Rock, AR 72205, United States. udupakodetthoor@uams.edu
Telephone: +1-501-2575566 Fax: +1-501-2575572
Received: July 29, 2006
Revised: September 1, 2006
Accepted: September 8, 2006
Published online: December 14, 2006
Revised: September 1, 2006
Accepted: September 8, 2006
Published online: December 14, 2006
Abstract
Erythropoietin (Epo) is the regulator of red blood cell formation. Its receptor (EpoR) is now found in many cells and tissues of the body. EpoR is also shown to occur in tumor cells and Epo enhances the proliferation of these cells through cell signaling. EpoR antagonist can reduce the growth of the tumor in vivo. In view of our current knowledge of Epo, its recombinant forms and receptor, use of Epo in cancer patients to enhance the recovery of hematocrit after chemotherapy treatment has to be carefully evaluated.
Keywords: Erythropoietin, Tumor cell, Receptor, Cell signaling, Proliferation, Erythroid cell