Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

doi:10.3748/wjg.v12.i43.7029

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Nov 21, 2006 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2006; 12(43): 7029-7032
Published online Nov 21, 2006. doi: 10.3748/wjg.v12.i43.7029

Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

Kuo-Ching Yang, Alexander Chu, Chao-Sheng Liao, Yu-Min Lin, Gen-Min Wang

Kuo-Ching Yang, Alexander Chu, Chao-Sheng Liao, Yu-Min Lin, Gen-Min Wang, Division of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, China

Kuo-Ching Yang, Taipei Medical University, Taipei, Taiwan, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Alexander Chu, Division of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, No. 95 Wen Chang Road, Shih Lin District, Taipei, Taiwan, China. alex.kec@msa.hinet.net

Telephone: +886-2-28332211 Fax: +886-2-28389335

Received: July 23, 2006
Revised: August 16, 2006
Accepted: August 29, 2006
Published online: November 21, 2006

Abstract

AIM: To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer.

METHODS: A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy: normal control group (25 patients) and gastric cancer group (29 patients). Both groups were further divided into H pylori (+) and H pylori (-) subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique (HelicoBlot 2.0, Genelabs Diagnostics, Singapore).

RESULTS: The positive rate of the immunoblotting test was as high as 88.9% in the H pylori (-) gastric cancer group and only 14.3% in the H pylori (-) normal control group with a statistically significant difference.

CONCLUSION: The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.

Keywords: Western blot, Immunoblotting, Gastric cancer, H pylori, Enzyme-linked immunosorbent assay