Rapid Communication
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Nov 14, 2006; 12(42): 6865-6868
Published online Nov 14, 2006. doi: 10.3748/wjg.v12.i42.6865
Insulin resistance in H pylori infection and its association with oxidative stress
Mehmet Aslan, Mehmet Horoz, Yasar Nazligul, Cengiz Bolukbas, F Fusun Bolukbas, Sahbettin Selek, Hakim Celik, Ozcan Erel
Mehmet Aslan, Mehmet Horoz, Department of Internal Medicine, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Yasar Nazligul, Cengiz Bolukbas, F Fusun Bolukbas, Department of Gastroenterology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Sahbettin Selek, Hakim Celik, Ozcan Erel, Department of Clinical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Mehmet Aslan, Department of Internal Medicine, Faculty of Medicine, Harran University, Bahcelievler Mah, Sema Apt A, Blok No. 8, Sanliurfa 63200, Turkey. m.aslan301@mynet.com
Telephone: +90-414-3140216 Fax: +90-414-3140216
Received: April 4, 2006
Revised: April 20, 2006
Accepted: April 24, 2006
Published online: November 14, 2006
Abstract

AIM: To determine the insulin resistance (IR) and oxidative status in H pylori infection and to find out if there is any relationship between these parameters and insulin resistance.

METHODS: Fifty-five H pylori positive and 48 H pylori negative patients were enrolled. The homeostasis model assessment (HOMA) was used to assess insulin resistance. Serum total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined in all subjects.

RESULTS: The total antioxidant capacity was significantly lower in H pylori positive group than in H pylori negative group (1.36 ± 0.33 and 1.70 ± 0.50, respectively; P < 0.001), while the total oxidant status and oxidative stress index were significantly higher in H pylori positive group than in H pylori negative group (6.79 ± 3.40 and 5.08 ± 0.95, and 5.42 ± 3.40 and 3.10 ± 0.92, respectively; P < 0.001). Insulin resistance was significantly higher in H pylori positive group than in H pylori negative group (6.92 ± 3.86 and 3.61 ± 1.67, respectively; P < 0.001). Insulin resistance was found to be significantly correlated with total antioxidant capacity (r = -0.251, P < 0.05), total oxidant status (r = 0.365, P < 0.05), and oxidative stress index (r = 0.267, P < 0.05).

CONCLUSION: Insulin resistance seems to be associated with increased oxidative stress in H pylori infection. Further studies are needed to clarify the mechanisms underlying this association and elucidate the effect of adding antioxidant vitamins to H pylori eradication therapy on insulin resistance during H pylori infection.

Keywords: H pylori; Insulin resistance; Total antioxidant capacity; Total oxidant status; Oxidative stress index