Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jan 28, 2006; 12(4): 665-667
Published online Jan 28, 2006. doi: 10.3748/wjg.v12.i4.665
Coexistence of hepatocellular carcinoma and gastrointestinal stromal tumor: A case report
Radoslaw Jaworski, Tomasz Jastrzebski, Maciej Swierblewski, Kamil Drucis, Grazyna Kobierska-Gulida
Radoslaw Jaworski, Tomasz Jastrzebski, Maciej Swierblewski, Kamil Drucis, Department of Surgical Oncology, Medical University of Gdansk, Poland
Grazyna Kobierska-Gulida, Department of Pathology, Medical University of Gdansk, Poland
Correspondence to: Kamil Drucis, Klinika Chirurgii Onkologicznej Akademii Medycznej w Gdansku, Debinki 7, 80-211 Gdansk, Poland. kamil@tsi.pl
Telephone: +4858-349-2440 Fax: +4858-301-7114
Received: May 26, 2005
Revised: June 8, 2005
Accepted: June 18, 2005
Published online: January 28, 2006
Abstract

Malignant gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating from the wall of the gastrointestinal tract. Their coexistence with other tumors originating from other germ layers is unique. We have reported a case of a 63-year-old GIST patient presenting as an epigastric mass associated with hepatic tumor. Histologically, the mesenteric tumor was composed of spindle cells showing both neural and smooth muscle differentiation. Immunohistochemical examination showed positive staining for CD117, vimentin, S-100, and SMA, while CD34 antigen was negative. The hepatic tumor was diagnosed as hepatocellular carcinoma (HCC). To the best of our knowledge, this is the first case of GIST and HCC coexistence. The rarity of the case, however, should not lead to ignoring such a possibility in differential diagnosis.

Keywords: Malignant GIST, Hepatocellular carcinoma, Coexistence of GIST and HCC