H Pylori
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Oct 21, 2006; 12(39): 6310-6315
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6310
Does delayed gastric emptying shorten the H pylori eradication period? A double blind clinical trial
Mohammad Hassan Emami, Mohammad Mehdi Saberfiroozi, Abbas Arj, Ali Reza Taghavi, Kamran Bagheri-Lankarani, Najaf Dehbashi, Mohammad Reza Fattahi, Mahvash Alizadeh, Mohammad Javad Kaviani, Rahim Bahri-Najafi, Bita Geramizadeh, Abbas Esmaeili
Mohammad Hassan Emami, Gastroenterologist, Isfahan University of Medical Sciences, Poursina Hakim Research Institute, Isfahan, Iran
Mohammad Mehdi Saberfiroozi, Ali Reza Taghavi, Kamran Bagheri-Lankarani, Najaf Dehbashi, Mohammad Reza Fattahi, Mahvash Alizadeh, Mohammad Javad Kaviani, Bita Geramizadeh, Gastroenterologist, Namazi University Hospital, School of Medicine, Shiraz University of Medical Sciences, Isfahan, Iran
Abbas Arj, Gastroenterologist, School of Medicine, Kashan University of Medical Sciences, Isfahan, Iran
Rahim Bahri-Najafi, Clinical Pharmacist, Pharmaceutical School, Shiraz University of Medical Sciences, Shiraz, Iran
Abbas Esmaeili, General Practitioner, Poursina Hakim Research Institute, Isfahan, Iran
Supported by the Namazi university hospital, with full financial support of Shiraz University of Medical Sciences, Shiraz, Iran
Correspondence to: Mohammad Hassan Emami, Isfahan University of Medical Sciences, Poursina Hakim Research Institute, Mail box: 81465-1798, Isfahan, Iran. mh_emami@med.mui.ac.ir
Telephone: +98-913-3094147 Fax: +98-311-2667542
Received: January 16, 2006
Revised: January 28, 2006
Accepted: February 24, 2006
Published online: October 21, 2006
Abstract

AIM: To evaluate the gastric emptying inhibitory effects of sugar and levodopa on H pylori eradication period.

METHODS: A total of 139 consecutive patients were randomized into 6 groups. The participants with peptic ulcer disease or non-ulcer dyspepsia non-responding to other medications who were also H pylori-positive patients either with positive rapid urease test (RUT) or positive histology were included. All groups were pretreated with omeprazole for 2 d and then treated with quadruple therapy regimen (omeprazole, bismuth, tetracycline and metronidazole); all drugs were given twice daily. Groups 1 and 2 were treated for 3 d, groups 3, 4 and 5 for 7 d, and group 6 for 14 d. Groups 1 to 4 received sugar in the form of 10% sucrose syrup. Levodopa was prescribed for groups 1 and 3. Patients in groups 2 and 4 were given placebo for levodopa and groups 5 and 6 received placebos for both sugar and levodopa. Upper endoscopy and biopsies were carried out before treatment and two months after treatment. Eradication of H pylori was assessed by RUT and histology 8 wk later.

RESULTS: Thirty patients were excluded. Per-protocol analysis showed successful eradication in 53% in group 1, 56% in group 2, 58% in group 3, 33.3% in group 4, 28% in group 5, and 53% in group 6. Eradication rate, patient compliance and satisfaction were not significantly different between the groups.

CONCLUSION: It seems that adding sugar or levodopa or both to anti H pylori eradication regimens may lead to shorter duration of treatment.

Keywords: H pylori; Gastric emptying; Glucose; Levodopa