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World J Gastroenterol. Oct 14, 2006; 12(38): 6212-6215
Published online Oct 14, 2006. doi: 10.3748/wjg.v12.i38.6212
Relationship between antioxidant capacity and oxidative stress in children with acute hepatitis A
Mustafa Cemek, Semiha Dede, Fahri Bayiroğlu, Hüseyin Çaksen, Fatma Cemek, Nihat Mert
Mustafa Cemek, Department of Chemistry (Biochemistry Division), Faculty of Science, Afyon Kocatepe University, Afyon, Turkey
Semiha Dede, Nihat Mert, Department of Biochemistry, Faculty of Veterinary Medicine, Yüzüncü Yıl University, Van, Turkey
Fahri Bayiroğlu, Department of Physiology, Faculty of Veterinary Medicine, Yüzüncü Yıl University, Van, Turkey
Hüseyin Çaksen, Fatma Cemek, Department of Pediatrics, Faculty of Medicine, Yüzüncü Yıl University, Van, Turkey
Correspondence to: Dr. Mustafa Cemek, Afyon Kocatepe Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Biyokimya AD. ANS Kampüsü Afyon, Turkey. mcemek@yahoo.com
Telephone: +90-272-2281312 Fax: +90-272-2281235
Received: June 7, 2006
Revised: June 28, 2006
Accepted: July 7, 2006
Published online: October 14, 2006
Abstract

AIM: To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA, an indicator of oxidative stress) and nonenzymic antioxidants in children with acute hepatitis A.

METHODS: Whole blood MDA and reduced glutathione (GSH), serum β-carotene, retinol, vitamin E and vitamin C levels were studied in 19 (10 females, 9 males) children with acute hepatitis A and in 29 (13 females, 16 males) healthy control subjects.

RESULTS: There was a statistically significant difference between patients and controls for all parameters (P < 0.05). Lipid peroxidation marker MDA was significantly elevated (P < 0.001), while antioxidants β-carotene, retinol and GSH were significantly decreased (all P < 0.001) in patients compared to healthy subjects. In addition, α-tocopherol and ascorbic acid levels were significantly lower in patients when compared to age and sex matched controls (P < 0.05, P < 0.01, respectively).

CONCLUSION: Our study shows that hepatitis A virus induces oxidative stress in childern with hepatitis A. This finding could be taken into consideration to improve the therapeutic approach in acute hepatitis A.

Keywords: Antioxidant; Oxidative stress; Hepatitis A; Child