H Pylori
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Sep 21, 2006; 12(35): 5658-5662
Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5658
H pylori infection and reflux oesophagitis: A case-control study
Rahim Masjedizadeh, Eskandar Hajiani, Koorosh MoezArdalan, Saeed Samie, Mohammad-Javad Ehsani-Ardakani, Ali Daneshmand, Mohammad-Reza Zali
Rahim Masjedizadeh, Eskandar Hajiani, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran
Koorosh MoezArdalan, Saeed Samie, Mohammad-Javad Ehsani-Ardakani, Ali Daneshmand, Mohammad-Reza Zali, The National Research Department of Foodborne Diseases (NRDFD), The Research Center of Gastroenterology and Liver Diseases (RCGLD), Shaheed Beheshti University of Medical Sciences, Iran
Author contributions: All authors contributed equally to the work.
Supported by the Research Center of Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, grant No. EPS/00/114
Correspondence to: Dr. Eskandar Hajiani, Assistant Professor of Gastroenterology and Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Golestan Hospital, Ahwaz Jundishapur University of Medical Sciences, PO Box 89, Ahwaz, Iran. ehajiani@ajums.ac.ir
Telephone: +98-611-5530222 Fax: +98-611-3340074
Received: December 27, 2005
Revised: January 15, 2006
Accepted: January 24, 2006
Published online: September 21, 2006
Abstract

AIM: To examine the relationship between H pylori and gastro-oesophageal reflux disease (GORD) in Iran.

METHODS: In this study 51 GORD patients (referred to endoscopy at Taleghani hospital) were compared with 49 age-sex matched controls. Diagnosis of H pylori was made by gastric mucosal biopsy and rapid urease test (positive if the result of one or both diagnostic methods was positive). Updated Sydney system was used to report histopathological changes.

RESULTS: The frequency of H pylori infection based on rapid urease test and histology was 88.2% (45) in patients and 77.6% (38) in controls, which showed no significant difference. The frequency of H pylori infection was significantly higher in the antrum than in the corpus and cardia. The mean activity, inflammation, and gastritis scores were also higher in the antrum of patients than in the antrum of controls. The mean scores were significantly higher in the corpus of controls than in the corpus of patients. Diffuse active gastritis was observed in a significantly larger number of controls, while the frequency of diffuse chronic gastritis was higher in patients. There was no significant difference in the frequency of other histological findings between patients and controls.

CONCLUSION: H pylori infection cannot prevent GORD in this region.

Keywords: H pylori, Gastro-oesophageal reflux diseases, Reflux oesophagitis