Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Sep 14, 2006; 12(34): 5573-5576
Published online Sep 14, 2006. doi: 10.3748/wjg.v12.i34.5573
Mucosa-associated lymphoid tissue lymphoma of the transverse colon: A case report
Shigetoshi Matsuo, Yohei Mizuta, Tomayoshi Hayashi, Seiya Susumu, Ryuji Tsutsumi, Takashi Azuma, Satoshi Yamaguchi
Shigetoshi Matsuo, Seiya Susumu, Ryuji Tsutsumi, Takashi Azuma, Satoshi Yamaguchi, Department of Surgery, Nagasaki Prefectural Shimabara Hospital, Shimabara, Nagasaki, Japan
Yohei Mizuta, Second department of Internal medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Tomayoshi Hayashi, Department of Pathology, Nagasaki Prefectural Shimabara Hospital, Shimabara, Nagasaki, Japan
Correspondence to: Dr. Shigetoshi Matsuo, Department of Surgery, Nagasaki Prefectural Shimabara Hospital, 7895 Shimokawajiri, Shimabara, Nagasaki 855-0861, Japan. shigetoshi-matsuo@pref.nagasaki.lg.jp
Telephone: +81-957-631145 Fax: +81-957-634864
Received: June 7, 2006
Revised: June 28, 2006
Accepted: July 7, 2006
Published online: September 14, 2006
Abstract

We herein present a case of a 75-year-old female with mucosa-associated lymphoid tissue (MALT) lymphoma of the transverse colon with the stage IE (Ann Arbor classification). Colonoscopy revealed the tumor’s appearance as a IIa plus IIc-like early colon cancer as defined according to the macroscopic classification of the Japanese Research Society for Cancer of Colon, Rectum and Anus, measuring less than 2 cm in diameter. Histologically, the tumor was diagnosed as MALT lymphoma because of the presence of lymphoepithelial lesions consisting of diffuse proliferation of atypical lymphocytes and glandular destruction. The majority of these lymphocytes immunohistochemically stained for the B-lymphocyte marker. The patient first underwent H pylori eradication therapy with Lansap®. However, the tumor size gradually increased over the next 4 mo and the patient eventually underwent surgical resection. The operative procedure included a partial colectomy with dissection of the paracolic lymph nodes. The tumor measured 45 mm x 30 mm in diameter and histological examination showed that the lymphoma cells had infiltrated the muscle layer of the colon without nodal involvement. The patient has had no recurrence postoperatively without any chemotherapy.

Keywords: Mucosa-associated lymphoid tissue; Malignant lymphoma