H Pylori
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Sep 14, 2006; 12(34): 5479-5482
Published online Sep 14, 2006. doi: 10.3748/wjg.v12.i34.5479
H pylori infection among 1000 southern Iranian dyspeptic patients
Mahmood Reza Hashemi, Mohammad Rahnavardi, Bavand Bikdeli, Mohsen Dehghani Zahedani
Mahmood Reza Hashemi, Department of Gastroenterology, Hormozgan University of Medical Sciences, Bandarabbas, Artesh University of Medical Sciences, Tehran, Iran
Mohammad Rahnavardi, Bavand Bikdeli, Educational Development Center, Artesh University of Medical Sciences, Tehran, Iran
Mohsen Dehghani Zahedani, Department of Pathology, Bandarabbas University of Medical Sciences, Bandarabbas, Iran
Correspondence to: Mohammad Rahnavardi, MD, 33, unit 16, Golshahr Blvd, Africa Blvd, Tehran 1915665144, Iran. rahnavardi@gmail.com
Telephone: +98-912-3092024 Fax: +98-21-88797363
Received: June 13, 2006
Revised: June 28, 2006
Accepted: July 7, 2006
Published online: September 14, 2006

AIM: To describe the frequency of H pylori infection among 1000 southern Iranian dyspeptic patients.

METHODS: A prospective study was performed in a referral hospital in south of Iran from 1999 to 2005. One thousand dyspeptic patients (518 males, mean ± SD age of 49.12 ± 12.82 years) consecutively underwent upper gastrointestinal endoscopy. Multiple gastric antral biopsy samples were taken from all patients for rapid urease test and histopathologic examination (96.9% satisfactory samples). Patients were considered H pylori-infected if one or both tests were positive.

RESULTS: Six hundred and seventy-one patients (67.1%, 95% confidence interval [CI]: 64.2%-70.0%) were H pylori-infected. H pylori positivity was significantly more frequent in patients with peptic ulcer disease (PUD) than in those with non-ulcer dyspepsia (P < 0.001). Male-to-female ratio for duodenal and gastric ulcers was 2.7:1 and 1.5:1, respectively. Moreover, the duodenal-to-gastric ulcer ratio was 1.95:1. The frequency of H pylori infection among those with endoscopic diagnosis of gastritis, duodenal ulcer, gastric ulcer, and normal mucosa was 70.1% (398/568), 86.2% (150/174), 71.9% (64/89), and 33.5% (54/161), respectively. H pylori infection, male sex, and older age were independently associated with PUD in multivariate analysis. H pylori positivity was associated with chronic gastritis, and chronic active gastritis with odds ratios of 34.21 (95% CI: 12.19%-96.03%) and 81.21 (95% CI: 28.85%-228.55%), respectively.

CONCLUSION: H pylori and PUD are highly frequent in dyspeptic patients from south of Iran. H pylori is a cardinal risk factor for chronic active or inactive gastritis.

Keywords: Dyspepsia, H pylori, Iran