Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Aug 28, 2006; 12(32): 5253-5255
Published online Aug 28, 2006. doi: 10.3748/wjg.v12.i32.5253
Fulminant hepatic failure caused by Salmonella paratyphi A Infection
Fahmi Yousef Khan, Ahmed A Kamha, Ibrahim Y Alomary
Fahmi Yousef Khan, Ahmed A Kamha. Ibrahim Y Alomary, Department of Medicine, Hamad General Hospital, Doha, Qatar
Author contributions: All authors contributed equally to the work.
Correspondence to: Fahmi Yousef Khan, MD, Senior specialist, Department of Medicine, Hamad General Hospital, PO Box 3050, Doha, Qatar.
Telephone: +974-5275989 Fax: +974-4879228
Received: April 26, 2006
Revised: July 15, 2006
Accepted: July 22, 2006
Published online: August 28, 2006

We report a case of fulminant hepatic failure associated with Salmonella paratyphi A infection, in a 29-year-old patient who was admitted to the intensive care unit (ICU) with fever of two days, headache and vomiting followed by behavioural changes and disorientation. On examination, the patient appeared acutely ill, agitated, confused, and deeply jaundiced. Temperature 38.5°C, pulse 92/min, blood pressure 130/89 mmHg. Both samples of blood grew S. paratyphi A, which was sensitive to ceftriaxone and ciprofloxacin. Ceftriaxon was administered with high-dose dexamethasone. Two weeks after treatment with ceftriaxon, the patient was discharged in satisfactory condition.

Keywords: Typhoid hepatitis, Fulminant hepatic failure, Salmonella paratyphi A