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Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Aug 28, 2006; 12(32): 5196-5200
Published online Aug 28, 2006. doi: 10.3748/wjg.v12.i32.5196
Smoking is not associated with nonalcoholic fatty liver disease
Norberto C Chavez-Tapia, Javier Lizardi-Cervera, Oliver Perez-Bautista, Martha H Ramos-Ostos, Misael Uribe
Norberto C Chavez-Tapia, Javier Lizardi-Cervera, Oliver Perez-Bautista, Martha H Ramos-Ostos, Misael Uribe, Departments of Gastroenterology and Internal Medicine. Medica Sur Clinic and Foundation, Mexico City, Mexico
Author contributions: All authors contributed equally to the work.
Correspondence to: Norberto C Chavez-Tapia, MD, Departments of Gastroenterology and Internal Medicine, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col Toriello Guerra, Mexico City, Mexico. khavez@hotmail.com
Telephone: +52-55-56066222-4119 Fax: +52-55-56664031
Received: February 20, 2006
Revised: March 5, 2006
Accepted: March 11, 2006
Published online: August 28, 2006

AIM: To analyze the relationship between smoking and nonalcoholic fatty liver disease (NAFLD).

METHODS: This is a cross-sectional study of a healthy population, carried out in a check-up unit of a university hospital in Mexico City. We enrolled 933 subjects, 368 current smokers (cases) and 565 persons who had never smoked (controls). Demographic, metabolic and biochemical variables were measured in the two groups. NAFLD was determined by ultrasound and metabolic syndrome according to ATPIII.

RESULTS: A total of 548 men (205 cases and 343 controls) and 337 women (114 cases and 223 controls) were included in the analysis. Statistical differences between cases and controls were observed only in high blood pressure prevalence (6.6% vs 11.3%, P < 0.05; cases and controls respectively), high-density lipoproteins (1.00 ± 0.26 vs 1.06 ± 0.28 mmol/L, P < 0.005), triglycerides (2.18 ± 1.49 vs 1.84 ± 1.1 mmol/L, P < 0.001), and erythrocyte sedimentation rate (11.3 ± 9.3 vs 13.5 ± 11.9 mm/h, P < 0.001). No differences were observed in the prevalence of NAFLD (22.27% vs 29.68%, P = NS) and metabolic syndrome (41.69% vs 36.74%, P = NS). Univariate analysis showed that smoking was not a risk factor for NAFLD (OR = 0.89, 95% CI 0.65-1.21).

CONCLUSION: No differences in NAFLD prevalence were observed between current smokers and nonsmokers, and furthermore, no differences were observed in heavy smokers (more than 20 packs/year), indicating that there is no relationship between smoking and NAFLD.

Keywords: Smoking, Nonalcoholic fatty liver disease, Metabolic syndrome