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World J Gastroenterol. Jul 28, 2006; 12(28): 4578-4581
Published online Jul 28, 2006. doi: 10.3748/wjg.v12.i28.4578
Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis
Hao Yuan, Wan-Sheng Ji, Ke-Xiang Wu, Jian-Xin Jiao, Liang-Hua Sun, Yong-Tang Feng
Hao Yuan, Wan-Sheng Ji, Department of Internal Medicine, Weifang Medical College, Weifang 261042, Shandong Province, China
Ke-Xiang Wu, Jian-Xin Jiao, Liang-Hua Sun, the Affiliated Hospital of Weifang Medical College, Weifang 261031, Shandong Province, China
Yong-Tang Feng, Laboratory of Molecular Immunology, Weifang Medical College, Weifang 261042, Shandong Province, China
Supported by the Health Ministry of Shandong Province, No. 2005HW147
Correspondence to: Hao Yuan, Department of Internal Medicine, Weifang Medical College, Weifang 261042, Shandong Province, China. 91chuhan@163.com
Telephone: +86-536-2101571
Received: February 24, 2006
Revised: March 12, 2006
Accepted: March 27, 2006
Published online: July 28, 2006
Abstract

AIM: To explore the anti-inflammatory mechanism of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis induced by acetic acid.

METHODS: Spragur-Dawley female rats were divided into four groups: Diammonium Glycyrrhizinate group, dexamethasone group, acetic acid control and normal control group. Colonic inflammation was evaluated by disease activity index, gross morphologic damage, histological injury and colonic myeloperoxidase activity. Immunohistochemistry was used to detect the expression of NF-κB, TNF-α and ICAM-1 in colonic mucosa.

RESULTS: Compared to the acetic acid control, both Diammonium Glycyrrhizinate and dexamethasone showed a significant anti-inflammatory effect (P < 0.01). The expression of NF-κB, TNF-α and ICAM-1 in colonic mucosa was significantly lower in the Diammonium Glycyrrhizinate group and dexamethasone group than in the acetic acid group.

CONCLUSION: Diammonium Glycyrrhizinate could reduce inflammatory injury in a rat model of ulcerative colitis. This may occur via suppression of NF-κB, TNF-α and ICAM-1 in colonic mucosa.

Keywords: Ulcerative colitis; Diammonium Glycyrrhizinate; Mechanism