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Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jul 28, 2006; 12(28): 4553-4556
Published online Jul 28, 2006. doi: 10.3748/wjg.v12.i28.4553
Azithromycin in one week quadruple therapy for H pylori eradication in Iran
Shahrokh Mousavi, Jafar Toussy, Siamak Yaghmaie, Mehrdad Zahmatkesh
Shahrokh Mousavi, Jafar Toussy, Siamak Yaghmaie, Mehrdad Zahmatkesh, Semnan Gastrointestinal and Liver diseases Research Center, Semnan University of Medical Sciences, Semnan, Iran
Co-correspondence: Mehrdad Zahmatkesh
Correspondence to: Dr. Shahrokh Mousavi, Department of gastroenterology, Fatemieh hospital, Semnan university of medical sciences, PO Box 35195-16, Semnan, Iran. shahrokhmousavi@yahoo.com
Telephone: +98-231-3341449 Fax: +98-231-3328302
Received: January 31, 2006
Revised: February 12, 2006
Accepted: February 28, 2006
Published online: July 28, 2006

AIM: To investigate eradication rates, patient compliance and tolerability of a 1-wk Azithromycin-based quadruple therapy versus the 2-wk conventional therapy.

METHODS: A total of 129 H pylori-positive patients were randomized to either omeprazole 20 mg, bismuth subcitrate 240 mg, azithromycin 250 mg, and metronidazole 500 mg, all twice daily for 1-wk (B-OAzM) or omeprazole 20 mg, bismuth subcitrate 240 mg, amoxicillin 1g, and metronidazole 500 mg all twice daily for 2-wk (B-OAM). H pylori infection was defined at entry by histology and rapid urease test and cure of infection was determined by negative urea breath test.

RESULTS: H pylori eradication rates produced by B-OAzM and B-OAM were 74.1% and 70.4% respectively based on an intention to treat analysis, and 78.1% versus 75.7% respectively based on a per-protocol analysis. The incidence of poor compliance was lower, although not significantly so, in patients randomized to B-OAzM than for B-OAM (3.5% versus 4.3%) but intolerability was similar in the two groups ( 35% versus 33.3%).

CONCLUSION: 1-wk azithromycin based quadruple regimen achieves an H pylori eradication rate comparable to that of standard 2-wk quadruple therapy, and is associated with comparable patient compliance and complications.

Keywords: Peptic ulcer, Treatment, Azithromycin, H pylori, Non-ulcer dyspepsia